Synthesis And Properties Of 2H-chromene Derivatives As Well As Synthesis Of Vitamin D₂ Dimer

2H-chromene serves as an important structural component in many natural products and its derivatives have various biological activities such as anticancer, anti-inflammatory and antivirus activities. On the other hand, some of its derivatives, of which the coumarin is the best example, have good photochemical properties. This paper has focused on the modification of 2H-chromene and 2H-chromene-based fluorescent compounds.When heterocycles that have different biological activities are introduced into the same molecule, the resulting molecule’s biological activity will be improved considerably. In this paper, benzimidazole was connected to 2H-chromene to afford their hybrids. Salicylaldehyde and its deviratives served as the starting materials, which were first converted to 2H-chromene-3-carboxaldehyde and its derivatives, from which three 2H-chromene-benzimidazole hybrids were synthesized with o-diaminobenzene.In this paper, three 2H-chromene-based fluorescent compounds were desighed and two of them were synthesized. The first one was a coumarin-modified vitamin D2 derivative with good fluorescent and absorbant properties and it had potential application in the visual monitoring of vitamin D2 concentration. The second one was a malononitrile derivative of 2H-chromene and its potential application was studied initially.In addition, a vitamin D2 dimer was also synthesized. In this paper, a Click reaction was used to combine vitamin D2, a biologically active substance, to get its dimer, which had potential biological activity.