Studies On Acyl Radicals Generated From Aroyl Chlorides Via Photocatalysis

This thesis mainly focus on the following three chapters:Chapter 1: In recent years, photocatalytic reactions are widely used in organic synthesis, which is a very popular direction of the subject. As a green, clean, abundant and sustainable energy, visible light provides a new catalytic model for the traditional organic synthesis. Related researches in this area are still ongoing, so this chapter summarizes the recent achievements and innovations in the field of photocatalytic organic reactions published by the scientists.Chapter 2: 3,3-bis-substituted oxindole is a highly active molecular structure in natural products and drugs, so we have developed a photocatalytic reaction using aroyl chlorides as the new acyl radical source to synthesize it. With more atom economy, this photocatalytic method can synthesize the target molecular structure efficiently, expand the substrate scope for photocatalysis, and make progress in this area. Photoredox mechanism is applied in this reaction which need not additional oxidant or reductant, so this simple and effective catalytic cycle is very ideal.Chapter 3: Ergot alkaloids, a large species of substance with high physiological activity, have the common feature containing a tetracyclic indole structure:(+)-Lysergic acid. Unlike previous total synthesis of the structure, we design and experiment one-pot synthesis for the C ring first. We use methyl 3-(1H-indol-4-yl)acrylate and nitrostyrene as substrates, undergo Friedel-Crafts reaction and Michael reaction to obtain the product to finish this new method.