Synthesis Of Kung Fu Amide、thiazolidine Amide Derivative And The Synthesis Process Of Fenoxycarb

This paper is made up of three parts: Synthesis process of fenoxycarb; Synthesis and biological activity of N-aryl kung fu amides; Synthesis and biological activity of thiazolidine carboxamideFenoxycarb pure product is a new generation of insect growth regulator, which has a lot of advantages. For example,high efficiency, low toxicity and good environmental compatibility and so on.It also has insecticidal specificity and has a good effect on specific pests. The production process of previous fenoxycarb existed many defects, such as cumbersome process,arsh reaction conditions and the low yield, therefore this article mainly explores the production process of Fenoxycarb.In reference to the basis of previous documents and synthesis of fenoxycarb, this paper will explore the effects of solvent,temperature,catalyst,reaction time on the experimental results.We use 1H NMR, gas mass spectrometry, high performance liquid chromatography to identify structure and purity of fenoxycarb. By series of experiments and industrial production,we conclude the process conditions:at 130 °C of temperature, toluene as solvent, tetrabutylammonium bromide as catalyst, and 6 hours of reaction time.The structure of fenoxycarb is as follows:Due to the special character of the fluorine atoms,the physiological activity and stability of fluorinated compounds can be significantly increased by adding the fluorine atoms. The fluorine-containing pesticides now have become a very important future prospects in pesticide industry.In this paper,the N-R1-2-amino-3-methyl-5-chlorobenzamide and kung fu chloride can react and generate a new fluorine-containing organic compound. Moreover, by changing connection amino R1 group, we can get many different pesticides with many fluorinated derivatives.On the other hand, we explore the conditions of these reactions to improve the yield of the reaction as high as possible and then select a optimal rection condition.The structural formula is as follows:The cyano imino thiazolidine derivatives have good fungicidal activity. In this article, five kinds of new amides and alkyl amines are obtained by reaction of 2-carbonitrile imino-1,3-thiazolidine and effort chloride, chlorobenzoyl chloride, p-chlorobenzoyl chloride thiosulfate, 4-chloro diphenyl methyl chloride, 2-chloro-dimethyl acetal respectively. On the basis of thiazolidine, different substituents are introduced. Finally, we measured their bactericidal activities.