Study On An Integrated Device For Skin Wound Debridement And Regeneration

Skin is the important organ for human body. It is able to help human feel stimulus, regulate body’s temperature, excrete waste and protect body from damages. However, the skin wound caused by stimulates in vitro or diseases will bring great pain, even death. The debridement and regeneration of skin is the hot and difficult spot in surgery. The traditional methods of skin debridement and regeneration bring great pain and rejection to patients. It is meaningful to develop the indolent and efficient methods and the integrated devices which are used for skin debridement and regeneration. In view of the problem, this paper developed an integrated device for skin debridement and regeneration based on the ultrasonic indolent debridement and pressure atomizing wound dressing.Firstly, the theories of ultrasonic cavitation and pressure atomization were analyzed to design the general plan and structure of the integrated device. Then, the power supply, air-passage and method of supplying liquid were designed for ultrasonic debridement module in detail. The methods of pipeline sterilizing and the method of protecting the dressings in low temperature were developed for the wound dressing module. In the end, the prototype of integrated device was constructed to experimental testing.The structure of ultrasonic debridement module mainly involved power supply of the ultrasonic nozzle, air-passage of the ultrasonic nozzle and liquid supplying mode of the ultrasonic nozzle. The power supply consisted of the circuitries of generating square-wave, optical isolation, power amplification, tuning matching and frequency tracking by phase difference feedback. The air-passage designed for nozzle was analyzed by fluid simulation. The start-stop, direction and speed of the peristaltic pump were controlled by Transistor-Transistor Logic signal to guarantee the liquid supplying of nozzle stable and controllable.When designing the wound dressing module, the requirements of wound dressings, sterility and low temperature must be considered. Hence, liquid supply pipeline sterilization with medical alcohol and gas supply pipeline sterilization with air filter and their control methods were developed. Then, a little temperature controller which can be fixed on the injection pump was designed to protect the dressings and the dressings were maintained at 15 centigrade by PID algorithm.In experimental aspect, a prototype of integrated device was made to test the performance of ultrasonic debridement module and wound dressing module. The tests included ultrasonic power, efficiency of ultrasonic debridement affected by airflow, the ability of sterilization, the parameters of pressure atomization and the efficiency of pressure atomization. The results showed that the prototype was able to meet the design requirements. The integrated device did well in skin debridement and wound dressing. The sterilization rate of ultrasonic debridement can be up to 89%. What’s more, the efficiency of skin debridement and wound dressing had been highly raised. In the end, a contrast experiment for mouse skin debridement and wound dressing by the prototype was conducted. The healing rate of the mouse skin wound was observed and researched. After 15 days, the wound healing rate of those mice which were dealt with the integrated device reached 61%, better than the contrast group. The experiment showed that the integrated device had positive effect on skin debridement and regeneration.