Affection Of Lactic Acid Bacteria Fermentation On Related Serum Hormones And Four Item Of Renal Function In Hyperlipemia Rats

Objective:To study the affection of lactic acid bacteria fermentation on related serum hormones and four item renal function in hyperlipidemia rats.Methods:The rats were randomly divided into blank group, high-fat group, prevention of group 1(fed with bacteria 1), prevention of group 2 (fed with bacteria 2), prevention of group 3 (fed with bacteria 3). The blank group was given ordinary diet; high-fat group and the prevention of groups 1-3 were given high fat diet. Prevention of groups 1,2,3 were fed with lactic acid bacteria1,2,3 respectivly. After the first 14 days of experimentation,all groups were feeding with water but not food for 12 hours,then 16 rats (half male and half female) were randomly selected and killed from each group, the killed rats’blood serum was separated immediately.The results showed CHO and LDL-C of high fat blood serum was significantly increased, HDL-C was lowered significantly. The results indicated that model of rat hyperlipidemia was established successfully.After the modeled,the group of high fat rats were randomly divided into high-fat group, lipid-lowering group, drug group, treatment of group 1 (fed with bacteria 1), treatment of group 2 (fed with bacteria 2), treatment of group 3(fed with bacteria 3). Lipid-lowering group were fed based diet, high-fat group, the treatment of group 1,2,3 were fed with high fat diet,the drug group was fed with high fat diet and lipid-lowering drugs.A total of experiment cycle were 3,and each experiment cycle was 30d.There were 16 rats were taken blood from the heart to separate serum hormone,tested for hormones level and kidney biochemical indexes in each cycle.Results:Hyperlipidemia can cause thyroid stimulating hormone and leptin to rise, it cause possibly free thyroxine to rise. Hyperlipidemia can cause estradiol, progesterne and testosterone to decrease.Fed with high-fat diet and fermented lactic acid bacteria can cause estradiol and progesterne to rise, free thyroxine,leptin to decrease.It cause possibly growth hormone releasing hormone to decrease.In hyperlipidemic conditions, through the fermentation of lactic acid bacteria showed estradiol, progesterne and cortisol index was rise and thyroid stimulating hormone to decrease. Through drug showed progesterne, growth hormone releasing hormone, cortisol index to rise and thyroid stimulating hormone to decrease. Through ordinary diet showed progesterne, growth hormone releasing hormone, cortisol index to rise and thyroid stimulating hormone to decrease.Hyperlipidemia can cause serum uric acid to increase,it cause possibly creatinine,blood urea Nitrogen and phosphorus to increase. Fed with high-fat diet and fermented lactic acid bacteria can cause serum uric acid,creatinine,blood urea Nitrogen and phosphorus to decrease;In hyperlipidemic conditions,the results showed serum uric acid,creatinine. blood urea Nitrogen and phosphorus was decreased on the regulation of lactic acid bacteria, ordinary diet and drug.Conclusions:Hyperlipidemia can cause thyroid stimulating hormone, leptin and serum uric acid to rise, it can cause estradiol, progesterne and testosterone to decrease.Fed with high-fat diet and fermented lactic acid bacteria can cause estradiol and progesterne to rise, free thyroxine and leptin to decrease.In hyperlipidemic conditions, through the fermentation of lactic acid bacteria showed estradiol, progesterne and cortisol index was increase and thyroid stimulating hormone to decrease. Through drug showed progesterne, growth hormone releasing hormone, cortisol index to rise and thyroid stimulating hormone to decrease. Through ordinary diet showed progesterne, growth hormone releasing hormone, cortisol index to rise and thyroid stimulating hormone to decrease.