| Astragalus polysaccharide (Astragalus polysaccharides, APS) is a water-soluble compound polysaccharide, with a variety of biological activity cotaining mainly six monosaccharide composition arabinose, xylose, mannose, rat lee sugar, galactose and glucose, which are the main active ingredients of Astragalus.APS can improve the body’s antioxidant capacity, enhance the immunity of human body, healing animal viral disease, having important protective effect on the body;The APS can increase the utilization of nutrient in animal body, promote animal growth and the improve the yield and quality of meat、milk and eggs.moreover, The APS play an important role on anti-stress, regulate blood sugar level, anti-virus, Anti-aging and so on. APS have the characteristics of widely source, moderate price, minute side effects, no residue, etc.For further research on clinical pharmacological effects of APS and apply to the actual production of the cows, our research has been conducted to clinical application of security, the enhancement effect of immune function and regulation of antioxidant function of dairy cows.The main research results are as follows:1.To explore the effect of Astragalus polysaccharides on plasma biochemistry parameters, and the results offer support for its veterinary usage in clinic.40 Holstein cows in lactation period were selected and randomly divided into four groups, group I was pointed as control group, group Ⅱ、Ⅲ、Ⅳ were sequentially treated with Astragalus polysaccharides 10g,50g,50g, 100g/cow, for 10d. The date of first delivery,from the date of first delivery, observe and record each cow spirit, body temperature, respiration, pulse, feed intake, drinking, gait posture, mainland situation for 24 days.The serum was collected and blood routine and serum biochemical was measured at 0d, 10d, and 20d. The results show that,during the experiment, the experimental animals were healthy and lively, general signs are normal; With the increase of adding dose, the feeding group compared with blank control group routine blood indexes have no significant difference.Compared with the control group, there’s no significant difference (p>0.05) of plasma biochemistry parameters in test groups(except the TG), the content of TG in serum in test group lowered significantly (p<0.05). In the actual production condition, feeding the cows with recommendatory dosage of Astragalus polysaccharides was safe and reliable.10 times as the recommendatory dosage of Astragalus polysaccharides is also safe.2.The research aims to provide a reference for the clinical medicine by the study the effect of different dosage of astragalus polysaccharides on antibody level of cattle vaccinated with foot-and-mouth virus vaccine. Forty cattles were randomly divided into four groups(ten per group) with same age, pavity and weight..0g,5g,10g and 15g astragalus polysaccharides were added in the concentrated food each day for seven days, respectively. At the fourth day, the cattle in each group inoculated with serotype Asia 1 and O foot-and-mouth disease vaccine. The levels of type Asia 1 and type O foot-and-mouth virus antibodys antibodies were measured at the days 0,4,18,32,46 and 104.The result showed that astragalus polysaccharides can increase the level of foot-and-mouth virus specific antibody after vaccination (P<0.05), which was related with dosage of Astragalus polysaccharides. The study suggests that APS could be used as an immunopotentiator to prevent and cure the foot-and-mouth disease.3.The aim of this study was to analysis the Astragalus polysaccharides (APS) effect on antioxidant capacity of lactating Holstein cows. In trial,35 lactational holstein cows were randomly divided into 5 group (7 per group) with similar age, calving number, and weight. 0g,5g,10 g,50 g and 100 g APS were added to each group in-order with concentrated feed every day and lasting for 14 days. The total antioxidant capacity (T-AOC), activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the content of malondialdehyde (MDA) in serum were determined at 0 day,14th day and 24th day after feeding APS, respectively. The results show that T-AOC, activity of SOD and GSH-Px were significantly improved (P<0.05). and the content of MDA was significantly decreased (P<0.05) under the influence of the appropriate APS. The results indicate that addition of APS in daily ration can improve the antioxidant capacity of lactational cows and the suitable amount of APS is 10 g to 50 g per day for each cow.Conclusion:In conclusion, feeding the cows with recommendatory dosage of APS in the actual production condition was safe and reliable.10 times as the recommendatory dosage of APS was also safe, and APS was able to regard as a security antioxidant and immunopotentiator in cow breeding. |
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