The Applied Research Of Cortical Function Mapping In The Treatment Of Glioma In Functional Areas Of Language

Objective To study the cortical function mapping application in the treatment of glioma inthe brain language areas, in using of intraoperative cortical electrical stimulation to verify thecorrelation of brain function mapping to locate the language areas. Methods8patients withglioma in the left side of brian, to do cortical function mapping (BOLD-fMRI toscan)preoperative,to analysis and process the MRI image by MTALAB R2008a software andto develop individualized surgery planning. Awake craniotomy,in use of direct corticalelectrical stimulation to posite language area, to verify the correlation between the functionmapping locating language area with DCS. In order to maximize safety resection of the tumorand to protect the language features.Results Preoperative cortical mapping accuratly locateBroca’s area and Wernicke’s area, with a good imaging of the relation with tumor.To comparethe distance from the intraoperative DCS position，in8patients, the position of the Brocaarea,1case is the overlapping relationship (<10mm),6cases is neighboring relations (10~20mm), and1case is noconsistent relationship (>20mm); the positioning of Wernicke ’s area7cases is neighboring relations,1case is noconsistent relationship. Lesion resection in2cases, subtotal resection in4cases, subtotal in2cases. Transient aphasia in3cases,deterioration of language function does not appear.Conclusions Cortical functionmapping can noninvasively locate the language area and the structure of the relevantfunctional areas in brain tumor patients, individualizely assessment of surgical planning.Combining with cortical electrical stimulation the language area in wake-up surgery. It canincrease the extent of tumor resection and reduce postoperative morbidity and the lack oflanguage features, to improve quality of life of the patients.