Study Of The Correlation Factors Of Retinal Nerve Fiber Layer And Retinal Thickness Of Posterior Pole In Myopic By3D-Optical Coherence Tomography

Objective To investigate the association between myopic refraction and retinal nervefiber layer thickness (RNFLT) and retinal thickness of posterior pole which measured by3D-optical coherence tomography (3D-OCT) as well as the correlative parameters. To evaluatethe RNFLT and posterior pole’s retinal thickness of different age, sex and refractivecharacteristics in the Chinese myopia subjects and discuss the enabling factors between theparameters.Methods We chose340myopic subjects (168male cases,172female cases) whoseages ranged from18to47years. After proceeding the routine examination of ophthalmology,we examined the peripapillary RNFL and retinal thickness in posterior pole of the subject’seyes by3D-OCT. According to the degree of spherical equivalent, age and sex, subjects weredivided into groups. The relationship between the RNFLT or retinal thickness in posteriorpole parameters and refractive diopter was analyzed by the Pearson correlation analysis andLinear Regression. The comparison of ocular parameter in different groups was performed bythe One-Way-ANOVA. The parameters between male and female were analyzed by theIndependent sample t-test. The data was analyzed with SPSS15.0commercial statisticalsoftware.Results (1) Myopia also affected the RNFL thickness distribution. The superior,inferior, nasal and average RNFLT decreased with higher axial length and higher sphericalequivalent. As the axial length/diopter increased, the thickness of the temporal peripapillaryRNFL increased. Overall RNFL thickness decreased2.271mm/1mm of axial length, and 0.935mm/1D sphere. The average RNFLT were significantly lower in the high myopic eyesthan in the low to moderate myopic eyes. No significant associations were found betweenRNFLT and age or sex.(2) Negative correlations were found between axial length/diopter and the peripapillaryretinal thickness. The peripapillary retinal thickness decreased6.07mm/1mm of axial length,and2.54mm/1D sphere. As the axial length/diopter increased, the average inner ring macularthickness, outer ring macular thickness and total average macular thickness decreased. Therewas a positive correlation between the axial length and the average foveal thickness. Theretinal thickness in posterior pole was significantly lower in the high myopic eyes than in thelow to moderate myopic eyes. There was no correlation between age and retinal thickness inposterior pole. Female subjects have thinner retinal thickness of posterior pole than male.Conclusions (1) As the level of myopia increased, the thickness of average RNFLdecreased, the thickness of the temporal peripapillary RNFL increased and that of the superior,nasal, inferior peripapillary RNFL decreased. To research and make use of the rules of RNFLin myopia subjects deserve careful consideration. We should ponder early glaucoma if thestable parameters decrease or only the refractive errors and other liable factors of variability ifthe instable parameters decrease. There was no correlation between RNFL and age or sex.(2) Increasing myopia has been found to be accompanied with decrease in retinalthickness (except the thickness of average foveal) of posterior pole in eyes, which determinedthe macula generally flattens in myopia by thinning at the perifovea and thickening at thefoveal pit. There was no correlation between retinal thickness in posterior pole and age.Female subjects have thinner retinal thickness than male.