The Correlation Research Between CystatinC，β2-microglobulin And The Different Stage Of Chronic Kidney Disease

Objective: To determine the relationship between the serum level of Cystatin C(CysC),β2-microglobulin (β2-MG) and the different stage of chronic kidneydisease(CKD), as well as the correlation between Cys C and glomendar filtrationrate(GFR), the correlation between β2-MG and GFR. To analyze the changes anddiagnostic value of Cys C and β2-MG in different stage of CKD.Materials and methods:300patients who diagnosed withCKD from Qinghaiprovince people’s hospital were enrolled in this study. To Determine theirCys C,β2-MG and Scr, use MDRD formula to calculate eGFR, according to thecalculated eGFR divided patients into different groups. Based on the different groups,to study the correlation between serum level changes of Cystatin C, β2-MG and GFR,meanwhile, study the characteristics of Cystatin C and β2-MG by the characteristicof AUC~ROCand sensitivity for all the subjects to evaluate the diagnostic value ofCystatin C and β2-MG.Results: There is no statistical significance in the serum level of cystatin C,β2-microglobulin, Serum creatinine among CKDⅠstages patients and healthy controls.Compare to healthy controls and CKDⅠ the level of serum cystatinC,β2-microglobulin in CKDⅡstages patients had statistical signifcance. While thereis no significant difference in the serum level of Scr among CKD Ⅱpatients,compared with healthy control and CKDⅠ (P>0.05). Compare to CKD Ⅰand healthy controls the level of cystatin C,β2-microglobulin, Scr of CKDⅢ,Ⅳ,Ⅴstages had statistical signifcance. Correlation analysis shows, The serum Cys C,β2-MG for CKD patients and GFR were negatively correlated,(r is－0.965、－0.906);The sensitivity show,the serum level of Cys C among the patients of CKD Ⅱ is thebest,the sensitivity for Cys C, β2-MG and Serum creatinine are88.33%,45%,21.67%,respectively. The AUCROCfor Cys C, β2-MG and Scr are0.964、0.823、0.745. Thediagnostic value of Cys C is the best among cys C,β2-MG and Scr.Conclutions: The Cystatin C and beta2-microglobulin not only can be used as asensitive indicator of GFR during early evaluation for patients with chronic kidneydisease (CKD), but also the level of The Cystatin C and beta2-microglobulin has acertain clinical significance for Preliminary estimation of the degree of renal damageand guiding clinical stage in patients with chronic kidney disease (CKD).