Comparisons Of Different Equations For Estimated Glomerular Filtration Rate In Chinese Han Patients With Chronic Kidney Disease In Real World

Objective:Aim To understand the agreement,precision and accuracy between other estimated glomerular filtration rate?eGFR?equations and the Chronic Kidney Disease Epidemiology Collaboration?CKD-EPI?creatinine-cystatin C equation?EPI_Cr_CysC?.Methods:We conducted a cross-sectional study research of 1913 CKD patients.The eGFRs were calculated separately by creatinine clearance rate and Cockcroft-Gault equation corrected for standard body surface area?Ccr_BSA and eCcr_BSA?,CKD-EPI_creatinine equation?EPI_Cr?,CKD-EPI_cystatin C equation?EPI_CysC?,EPI_Cr_CysC equation,Modification of Diet in Renal Disease equation with standardized serum creatinine?MDRD?and full-age-spectrum creatinine equation?FAS?.And EPI_Cr_CysC equation was used as the reference.Results:When compared with EPI_Cr_CysC equation,EPI_Cr equation achieved the highest agreement in eGFR estimates[Lin's concordance correlation coefficient?95%CI?,0.936?0.930,0.941?].And eCcr_BSA and EPI_Cr equation achieved the first and second highest percent agreement in accurate classification of the CKD stage[percent agreement,72.55%VS 71.25%].MDRD equation got the minimal bias and was closely followed by EPI_Cr equation[median difference?95%CI?,-1.3?-2.0,-0.8?VS 2.5?1.7,3.3?mL/min/1.73m²].EPI_CysC and EPI_Cr equations achieved the first and second highest precision[IQR of the difference?95%CI?,12.2?11.6,12.9?VS.15.5?14.7,16.3?mL/min/1.73m²].EPI_Cr and MDRD equations performed similarly and tied for first place in 30%accuracy[1-P₃₀?95%CI?,18.6?16.9,20.4?%VS 18.6?16.8,20.3?%].Conclusion:For assessment of renal function,EPI_Cr equation performed the best and remained an acceptable alternative to EPI_Cr_CysC equation in the absence of cystatin C.