The Study Of Automated Synthesis Of [11C]Acetate And Its Pre-clinical Application

Positron Emission Tomography (PET) is a medical imaging modality. It canmap the distribution of positron emitting radiopharmaceuticals injected into the bodyto give the diagnostics.[11C]-Acetate is a PET radiopharmaceutical, whose PET-CTimaging has a high value in the diagnosis of brain tumor, liver tumor, prostate tumorand myocardial perfusion and oxygen consumption. For the clinical demand of thisradiopharmaceutical, the research of automated synthesis of11C-ACE wasperformed.The synthesis procedure was established according to the reported syntheticroutes and the equipments in our facility. Key procedures in the synthesis routeincluding gathering the raw material, the reaction conditions and the function andworking conditions of PS-AG cartridge used in the purification procedure was testedand established. The automated synthesis was achieved.To test the value of11C-ACE PET-CT imaging in differentiation diagnosis ofthe malignancy and benign of a tumor lesion, C6glioma, acute inflammation,chronic inflammation and granulomas rat model was established.11C-ACE and18F-FDG PET-CT was performed in those models. Imaging was analyzed by visualanalysis and semi quantitatively calculation to reveal the capability of both tracers indifferentiation diagnosis of the tumor model and non-tumor modes.Both11C-ACE and18F-FDG PET-CT can’t differentiate the C6glioma modelfrom the acute inflammation model.18F-FDG PET-CT has some difficulties indifferentiating C6glioma model from chronic inflammation model and granulomasmodel.11C-ACE PET-CT can’t differentiate C6glioma model from chronicinflammation model but can differentiate C6glioma model from granuloms model.So,11C-ACE may be a potential tracer for PET-CT in differentiation diagnosis ofmalignant tumor and granulomas lesions.