Relation Between Red Blood Cell Distribution Width And Left Ventricular Reverse Remodeling In Dilated Cardiomyopathy

Objectives：Left ventricular reverse remodeling (LVRR) is a marker ofa good prognosis in patients with dilated cardiomyopathy (DCM). High levelof red blood cell distribution width (RDW) may be related to bad outcomesin patients with DCM. However, the interface between LVRR and RDW isunknown. Our aim was to show that, a low RDW is a new predictor of LVRRin DCM patients.Methods：Newly diagnosed patients (n=145) with DCM, who had follow-upRDW and echocardiogram after9months in our hospital were evaluated. Thestudy cohort was divided into two groups: LVRR group (n=53) and non-LVRRgroup (n=92). Medical history, echocardiogram, and blood tests findingswere compared between the two groups. Multivariate adjusted logisticregression analysis was used to evaluate the correlation between baselineRDW, LVEDDI, left ventricular end-systolic diameter(LVESDI), QRS complexduration>120minutes(mns) and LVRR. A P-value of <0.05was consideredstatistically significant.Results: At baseline values, red blood cell distribution width(RDW) wasrelated to total bilirubin (TBIL), direct bilirubin(DBIL), alaninetransaminase (ALT), aspartate transaminase (AST), and high-densitylipoprotein (HDL)，however it was independent of disease severity [LVEDDIand left ventricular ejection fraction (LVEF)]. The independentpredictors of LVRR at baseline RDW values (odds ratio (OR)=1.45;95%confidence interval (CI),1.12to1.89; P=0.005) and at baseline LVEDDI(OR=1.79;95%CI,1.18to2.72; P=0.006) were statistically significant. conclusion：Both RDW and LVEDDI at baseline were independent predictorsof LVRR in DCM.