The Clinical Significance And Prognostic Value Of Detecting Serum Epidermal Growth Factor Receptor For Patients With Primary Non-small Cell Lung Cancer

In worldwide, lung cancer is one of the highest morbidity and mortality of malignanttumor. According to statistics, among the incidence of malignant tumor in2013Americalung cancer ranked second, but the mortality first. With the development of surgicaltechniques and the advent of molecular targeted drugs, the overall effectiveness of treatinglung cancer has greatly improved. However, there is a large difference in the prognosis ofpatients, because genetic and physiological conditions differ. How to determine theprognosis of patients with lung cancer accurately has important significance for guidingclinical treatment. Epidermal growth factor receptor (EGFR) is closely related to theproliferation, adhesion, invasion and metastasis of tumor cell, and induces tumorangiogenesis. Current study shows that EGFR was high expressed in tissue and serum ofnon-small cell lung cancers patients (NSCLC). However, these studies just focus on therelationship between EGFR expression and clinicopathological parameters in cancertissues. There is no report about the level of serum EGFR, particularly the value of thechanges of serum EGFR level in prognostic judgment before and after operation.Therefore, this study analysed the content changes of the level of serum EGFR before andafter operation in patients with NSCLC, and followed up the survival of patients. We havepreliminary clear the significance of the variation of postoperative serum EGFR levels inNSCLC patients for prognostic judgment.Objective: Observed the serum levels of EGFR in NSCLC patients, before and afteroperation and explored its application value in prognosis. Methods: Utilized enzyme linked immunosorbent assay (ELISA) in detecting serumlevels of EGFR of78NSCLC patients, before and after operation and determined theCut-off values of serum EGFR with ROC curve. Investigated the relationship betweenpreoperative EGFR levels and clinical pathological index and survival rate. According tothe changes of the serum EGFR content before and after the operation, analyzed itsapplication value in prognosis.Result: Compared with the patients in benign pulmonary disease group and healthygroup, preoperative serum EGFR of patients in NSCLC group increased significantly (t=2.626, P=0.009; t=2.383, P=0.017). The Cut-off values of EGFR analyzed with theROC curve was6.75μg/L. According to the values,78patients were divided into lowexpression group (27cases) and high expression group (51cases). Logistic regressionanalysis results show that a history of smoking, higher TNM stage and lymph nodemetastasis were the risk factors of high serum EGFR of NSCLS patients. Survival analysisshowed that survival time of preoperative patients in high EGFR expression group andpatients with postoperative EGFR>6.75μg/L significantly shortened. Cox proportionalhazards model analysis results show that the high serum EGFR level before operation isan independent factor to reduce the survival times of patients.Conclusions: To lung cancer patients who will accept radical resection, detectingpostoperative changes of serum EGFR earlier has good application value in prognosis.