The Study Of The Associated Factors Of Cancer-associated Hypercoagulation And Acute Ischemic Stroke

Background and Purpose—At present, cerebrovascular disease, heart disease andmalignant tumor constituted the three major cause of death in human disease.A causalrelationship between malignant cancer and thrombosis has been known since the19thcentury, The association between cancer and excessive blood coagulation has since thenattracted much attention. Nevertheless, the importance of paraneoplastichypercoagulability as a possible stroke etiology in patients with cancer has receivedrelatively little attention to date.Methods—We identified50patients with ischemic stroke sequentially admitted to firstAffiliated hospital of fujian medical university with the additional diagnosis of active andmalignant cancer from2010to2013as combined group(Stroke and cancer group,CG). Atthe same time，the patients without tumor experiencing a new infarct were consecutivelycollected as the stroke group matched with the experimental group on age，gender，andthe patients who receiving the treatment of cancer without stroke were consecutivelyselected as the tumor group matched with the experimental group on age，gender andsubtype of tumor．The risk factors of cerebral infarction occurred in patients withmalignant tumor were analyzed by regression sex control study.Results—Compared with the tumor group，the Combination Group had more patientswith metastasis tumor．Muhiple logistic regression analysis revealed that while plateletcount increasedBy1×10’/L．the probability of cerebral infarction in patient with malignant tumor wouldincrease by about2.2%(OR=1.022，95％CI1.006～1.038，P=0．003)。while D-dimerlevels increased By1.0mg/L，the probability of cerebral infarction in patient withmalignant tumor would increase by about6.7%(OR=1.067，95％CI1.049～1.086，P=0.001)。The elongation of activated partial thromboplastin time played a protectiverole for stroke in patients with malignant tumor，and1s of its reducing caused thepossibility of increasing cerebral infarction by9.3％(OR=0.907，95％CI0.964～0.956，P=0.007). Conclusions—confirm the concept of cancer-associated hypercoagulation as a widelyunderestimated important stroke risk factor in patients with cancer, especially in thosewith severely elevated D-dimer levels and platelet count at the same time in the absence ofconventional risk factors.