The Influence Of Glucocorticoid Use On Bone Mineral Density In Patients With Skin Diseases

[Objective]：To find out the the influence of glucocorticoid use on bone mineral density inpatients with skin diseases.[Methods]：Thirty-three patints of the glucocorticoid group were patients from theoutpatient or inpatient department of the First Affiliated Hospital of Fujian MedicalUniversity who use glucocorticoid to treat skin diseases. Thirty-three patients of otherclinical departments who didn’t use glucocorticoid were observed as the control group. Thepatients of two groups were matched in the aspect of age，sex and body mass index（BMI）.Bone mineral density of lumbar vertebra and bilateral femur were detected by dual-energyX-ray absorptiometry（DXA）. Clinical information was obtained from history-taking andmedical records. Statistical analysis between BMD and general information such as age，sex，the time of menopause and the usage of glucocorticoid was conducted.[Results]：1. Patients of the glucocorticoid group had significantly lower BMD and T-scoreof lumbar vertebra and bilateral femur than the control group.2.The incidence of abnormalbone mass of the glucocorticoid group was78.8%which was higher than that of the controlgroup(45.5%).There are significantly difference between the two groups.3. The glucocor-ticoid group had twenty-one female patients，which can divided into postmenopausal groupand premenopausal group. Postmenopausal group had lower BMD and T-score of lumbarvertebra than premenopausal group（P<0.05）. There were no significantly differencebetween the two groups on accumulated dose of glucocorticoid（P>0.05）.4. Themedium-term treatment group and long-term treatment group had lower BMD of lumbarvertebra and bilateral femur than the control group（P<0.05）. Moreover，there were nosignificantly difference on BMD between the short-term treatment group the control group（P>0.05）.5. The inverse correlation between the age and BMD of the patients of controlgroup was determined through linear-regression analysis. [Conclusions]: Glucocorticoid-induced osteoporosis（GIOP）were common in thosepatients who use glucocorticoid to treat skin diseases. Age and menopausal were riskfactors for osteoporosis. There was a correlation between duration of glucocorticoid usageand osteoporosis.