Change Of Immunoglobulin, Complement In The Peripheral Blood Of Patients With Epilepsy And The Correlation Between The Levels And Seizure Severity

Objective: To discuss the change of the levels of serum IgG, IgA, IgM andcomplement C3, C4in patients with epilepsy, and the correlation between the levels andseizure severity.Methods: Venous blood of57epilepsy patients without medication,46epilepsypatients with regular medication more than three months,54cases in normal control groupwere extracted. The concentrations of IgG, IgA, IgM and C3, C4were measured withscattering turbidimetry. Seizure severity was evaluated by NHS3in epilepsy patientswithout medication.Results: Lower serum IgG and IgA concentrations were measured in patients withsymptomatic epilepsy and non symptomatic epilepsy compared with control group (P <0.05). Serum IgM, C3, C4concentrations had no significant differences. Multivariatelogistic regression analysis revealed the eminent correlations between NHS3and serumIgA concentrations (β=-4.948, P=0.004). The concentrations of IgG and IgA declinedbetween epilepsy patients without medication and control group（P＜0．05）. Higher serumIgG and IgA concentrations were measured in patients with regular medication more thanthree months, compared with epilepsy patients without medication. The difference ofserum IgG concentration was statistically significant, but serum IgA concentrationwithout statistical significance.Conclusion: Epilepsy patients may have immunity factional disorder beforeantiepileptic drugs (AEDs) treatment. Seizure severity is positively correlated with serum IgA concentration. Epilepsy patients with regularly antiepileptic treatment can improvethe immune function.