| Objective:By analyzing the content of immunoglobulin and the level of complement in the serum of different types of sudden deafness patients,this study studied the correlation between the etiology of sudden deafness and the immunological inflammation,and analyzed whether it could be a biological guideline for the diagnosis of sudden deafness.At the same time,it lays the theoretical foundation for the future study of different types of sudden deafness.Methods:The subjects of this study were selected as the control group for 139 patients who were treated with sudden deafness and hospitalized in March 2016-March 2018 at the second affiliated Hospital of Kunming Medical University,and 107 patients who had a health check-up in hospital.Among them,74 men were in the experimental group(accounting for 53.24%),female patients 65(46.76%),the age of 46.81 ± 14.2 years old,all experimental subjects were conformed to the diagnostic criteria of "The diagnosis and treatment guidelines of Sudden Sensorineural Hearing Loss" of the Chinese Medical Association Department of Otorhinolaryngology in 2015.In the control group,58 men(54.2%)and 49 female(45.8%)were aged 44.33±11.37.The 139 patients diagnosed with sudden deafness were divided into four groups to carry out related studies according to the differences in the degree and frequency of hearing loss shown by the auditory threshold curve obtained by testing pure sound hearing:the first group of 30 people,which is a type of low-frequency decline;the second group of 33 people is a high-frequency decline type;the third group has 41 people,which is a flat decline type;the fourth group of 35 people is the all-deaf type.The experimental comparison group was 107 people,aged 44.33 ±11.37 years,58 men(54.20%),and 49 women(45.80%).The levels of serum immunoglobulin and complement in the sudden deafness group and the normal control group were measured and statistically analyzed.The same statistical analysis was carried out among the groups of sudden deafness.Results:?The serum level of IgG and C3 in the experimental group,who had sudden deafness,were significantly higher than those in the normal control group(P<0.05).The serumof IgA,IgM and C4 was no significant difference between experimental group and the normal control group(P>0.05).?Differences of low-frequency drop vs high-frequency drop,high-frequency drop,and full sputum immunoglobulin IgG among four groups of sudden deafness:low-frequency declining,high-frequency declining,flat declining,and full deafness Statistically significant(P<0.05),there was no statistically significant difference between the other groups in the comparison of immunoglobulin IgG(P>0.05).?Among the four groups of patients with sudden deafness in the low-frequency declining type,high-frequency declining type,flat declining type,and total delirium type,there was a statistically significant difference between the low frequency declining pattern and the complete deafness pattern of the complement C3(P<0.05).There was no significant difference between the other groups in the comparison of complement C3(P>0.05).Conclusions:?The level of immuneglobulin and complement in the patients with sudden deafness are statistically different from that in the normal control group,suggesting that the occurrence of sudden deafness may be related to the immune inflammatory injury in the inner ear.?The increase of serum level immunoglobulin IgG and complement C3 in patients in high-frequency declining type sudden deafness was more obvious than that with other types of sudden deafness,suggesting that the incidence of sudden deafness with high-frequency declining type may be more likely to be associated with immune damage in the inner ear.Relevance,monitoring of immuneglobulin and complement levels may have important clinical implications for the precise treatment of different types of sudden deafness. |
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