Expression And Significance Of ER And PR In Differentiated Thyroid Cancer

Objective:To investigate the relationship between the expression of estrogen receptor (ER) and progestogen receptor (PR) and gender, age, size of tumor, lymph node metastasis of differentiated thyroid cancer (DTC) patientsMethods:70cases of DTC patients, archived in2010-2012were selected (61cases of papillary thyroid carcinoma,9cases of thyroid follicular carcinoma),22cases of normal thyroid tissue near next to tumor tissue、46cases of nodular goiter and17cases of Thyroid adenoma.The expression of ER/PR was detected by using the immunohistochemical staining technique (SP method)Results:The positive rates of ER/PR in DTC thyroid tissue were21.4%(15/70),31.4%(22/70) respectively, whereas no expression of ER/PR in most cases of normal thyroid tissue、nodular goiter and Thyroid adenoma.(P<0.01). The expression of ER/PR in DTC might be related to lymph node metastasis (x2=16.913,6.327, P<0.05;x2=7.516,12.727, P<0.05, respectively). No relationship was founded between expression of ER/PR and gender, age, size of tumor, and histology type(P>0.05).Conclusion:The positive rate of ER/PR expression in DTC was higher than normal thyroid tissue、nodular goiter and Thyroid adenoma., which might be helpful in treatment of DTC in clinical practice.