Evaluation On Left Atrial Function In Patients With Alcoholic Cardiomyopathy By New Techniques Of Ultrasound

Objective: To evaluate the left atrial function in patients with alcoholiccardiomyopathy (ACM) by two-dimensional speckle tracking echocardiography(2D-STE), strain rate imaging and quantitative tissue velocity imaging (QTVI).Methods: We classified30ACM male patients who were diagnosed in thesecond affiliated hospital of dalian medical university from March2010to September2012to be experimental group. Entry criteria including: Daily drinking≥4bottles ofbeer(2200ml) or150g distilled liquor(125ml of alcohol),6~7days a week, more than10years.2. After ultrasound, ECG and clinical examination, absence of hypertension,diabetes, ischemic or vascular heart disease, arrhythmia and atrial fibrillation, use ofcardiac medications and other diseases which may cause changes in the structure andfunction of the heart.30age-matched heathy male who took routine examination in thesecond affiliated hospital of dalian medical university from March2010to September2012were also recruted as control group. Conventional echocardiography,2D-STE,SRI and QTVI parameters were performed in ACM group and controls.1. Conventionalparameters included left atrial minimum volume(LAVmin), left atrial maximumvolume(LAVmax), left atrial pre-atrial contraction volume(LAVp), left atrial maximumdiameter(LAMD), left atrial active ejection fraction(LAAEF) and left atrial passiveejection fraction(LAPEF).2.2D-STE parameters included the global peak atrial strainrate of systolic, early and late diastolic(SRs, SRe and SRa) of left atrial.3. SRIparameters included mean strain rate of early diastolic periods of left ventricular(ESR),late diastolic periods of left ventricular(ASR) and contraction period of left ventricular(SSR).4. QTVI parameters included peak myocardial velocity duringventricle contraction waves(Ssia, Slat), early diastole waves(Esia, Elat) and late diastolewaves(Asia, Alat) in the atrial septum and left atrial lateral wall.Results:1. Conventional parameters:Compared with the control group, LAVmax, LAVp, LAVmin, LAMD and LAAEFincreased significantly in ACM group(all P<0.05), whereas LAPEF decreasedsignificantly (P<0.05).2.2D-STE parameters:Compared with the control group, SRa increased significantly in ACM group(P<0.05), whereas SRs and SRe decreased significantly (both P<0.05).3. SRI parameters:Compared with the control group, ASR increased significantly in ACM group(P<0.05), whereas SSRs and ESR decreased significantly (both P<0.05).4. QTVI parameters:Compared with the control group, Asia, Alat significantly increased (both P<0.05),whereas Esia, Elat, Ssia, Slat significantly decreased (all P<0.05).5. Correlation analysis:Asia of ACM group was closely correlated with LAAEF（r=0.52, P<0.05）．Alat ofACM group was closely correlated with LAAEF（r=0.59, P<0.05）．Conclusion:1.2D-STE could be used to evaluate the left atrial function accurately in patientswith ACM.2. QTVI could be used to evaluate the left atrial function accurately in patientswith ACM.3. SRI is an accurate method to evaluate left atrial function in patients with ACM.