Preoperative Neutrophil-lymphocyte Ratio (NLR) On The Prognosis Of Breast Cancer Patients

Objective: In recent years, studies have found that tumor occurrence anddevelopment is closely related to inflammation, including neutrophils-lymphocyteratio (Neutrophil-to-Lymphocyte Ratio, NLR) is considered with a variety of tumors,including colorectal cancer, lung cancer, stomach cancer, liver cancer prognosis.Currently, research on NLR and prognosis of breast cancer is less, this article on therelationship between preoperative and postoperative NLR pathology and clinicalprognostic factors in patients with breast cancer study, the relationship between NLRand clinical evaluation of patients with breast cancer prognostic factors.Methods: A retrospective analysis from January2006to January2008,203casesof breast cancer patients treated in the first Affiliated Hospital of Dalian MedicalUniversity after surgery, the patient before surgery last blood statistical data. Recordage, white blood cell count (WBC), neutrophil count (N), lymphocyte count (L), NLRand postoperative pathological data were statistically analyzed. According to the ROCcurve, taking into account the sensitivity and specificity, select NLR=1.81as thecritical value, the patients were divided into low NLR group (NLR <1.81) and highNLR group (NLR>1.81). Two groups of patients analyzed clinicopathological factors,the relationship between progression-free survival and overall survival between. Alldata were statistically analyzed using spss17software testing standards set at P<0.05.NLR as the ratio of neutrophils and lymphocytes.Results: The analysis of the relationship between NLR and tumor staging surgery,found that with the later stages, the higher the blood of the NLR value, and thedifference was statistically significant (P <0.001); prior to analysis and clinical preoperative and postoperative pathological NLR the relationship between the factorsfound NLR and pathological stage (P <0.001) and tumor grade (P <0.05) weresignificantly correlated.203cases of patients relapse and the proportion of patientswithout recurrence were15%,34%; NLR>1.81, the number of which has not relapsedand relapsed patients were34%,14%. The difference was statistically significant (P<0.001); progression-free survival curves plotted Kaplan-Meier method, Log-rank testshowed statistically significant (P <0.001). In this study,203cases of breast cancer5-year survival rate was80.6%, which NLR>1.81group80.2%; NLR <1.81group88.1%. The difference was statistically significant (P=0.007)Summary1A preoperative breast cancer patients indicates higher NLR higher postoperativestaging.2preoperative NLR=1.81as the prognosis of breast cancer patients to determinethe cutoff value, preoperative NLR>1.81prognosis than NLR <1.81in patients withpoor prognosis.3Preoperative NLR can be used as prognostic breast cancer patients.