The Changes And Clinical Significance Of High Mobility Group Box-1and High Sensitivity C-reactive Protein In Patients Of Acute Coronary Syndromes

Objectives: explorer the alteration of high mobility group box-1(HMGB1) and highsensitivity C-reactive protein (hs-CRP) in patients of acute coronary syndromes (ACS), toreveal the relationship between inflammatory factor and ACS.Methods:57ACS patients who accepted coronary angiography in our hospital fromNovember2012to February2013are selected. The patients include30acute myocardialinfarction (AMI) and27unstable angina pectoris (UAP). ACS patients were divided into33single-vessel disease, and24multi-vessel disease based on the severity of coronaryartery Major advense cardiac event (MACE) happened in9AMI patients duringhospitalization.26asymptomatic healthy individuals who underwent annual health checkup were chosen as control. Serum HMGB1were measured by enzyme-linkedimmunosorbent assay (ELISA). And serum hs-CRP, total cholesterol (TC), triglyceride(TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol(LDL-C) were collected.Results: levels of HMGB1and hs-CRP in ACS patients were all higher than controlsubjects (P <0.05). There was no significant difference between AMI and UA in levels ofHMGB1(P>0.05). Levels of HMGB1and hs-CRP in ACS patient were positivelycorrelated (γ=0.343, P<0.05). Compared with the single-vessel disease, HMGB1remarkably increased in Multi-vessel disease (P<0.05). Levels of HMGB1and hs-CRP inMACE were higher than non-MACE (P<0.05). Conclusions:1. Serum HMGB1and hs-CRP levels significantly increase inACS Patients.2. Serum HMGB1and hs-CRP levels were positively correlated inACS patients.3. Compared with the single-vessel disease, HMGB1remarkably increased inMulti-vessel disease.4. Serum HMGB1and hs-CRP levels could be important predictors of MACE in ACSpatients.