Expression And Clinical Significance Of PTEN And FHIT In Cervical Cancer: A Meta-analysis

Background and objective:Colorectal cancer is a common disease which is the most serious threat to human health. The incidence of colorectal cancer is rapidly rising year by year in China. As the present combined therapy of colorectal cancer continues to progress, the survival rate of patients with colorectal cancer is improved, at least in some ways. However, the prognosis of patients is still not satisfactory. How to diagnosis early, make the individual treatment meet the requirements of patients perfectly and prevent the recurrence after radical mastectomy, is still some burning questions.At present many scholars have done a lot on the proven the relationship between PTEN and FHIT and tumor. Some remarkable progress has been made, but there are different between different conclusions. Expression of PTEN and FHIT in tumor cells is extremely complex. This study explores the expression and clinical significance of PTEN and FHIT in Cervical Cancer. So we can provide the theory basis for the diagnosis and prognosis judgement.Materials and methods：Original literature, conference proceedings, graduation thesis, were searched in academic periodical databases such as CNKI, Wanfang data, Weipu data, Pubmed, Web of Knowledge, and EBSCO host, from the date of their establishment to Dec.2013. According to the inclusion and exclusion criteria, literatures were chosen. Then the quality of the studies was assessed by two reviewers using the Newcastle-Ottawa Scale. Then the data were analyzed by RevMan5.0.24software. Odds ratio (OR) and95%confidence interval (95%CI) were used to calculate dichotomous data. Z test(=0.05) was used to hypothesis test. Chi-square test (=0.1) was used to detect the heterogeneity between studies, and I2test was used to do quantitative analysis. Sensitivity analysis was used to judge the stability and strength of results, if different test methods may influence the results.Result：A total of20literatures with1810cervical tissue specimens were included. Our data shows that:The expression of PTEN in cancer group was decreased significantly compared with normal group [OR=0.05，95%CI（0.02，0.10），P＜0.01] and adenoma group [OR=0.33，95%CI（0.19，0.55），P＜0.01]. The expression of PTEN in Dukes A+B stages was increased significantly than Dukes C+D stages [OR=3.95，95%CI（1.82，8.58），P＜0.01]. The expression of PTEN in well-differentiated group was increased compared with poorly differentiated group [OR=3.48，95%CI（2.30，5.27），P＜0.01]. The expression of PTEN in tissue with lymph node metastasis was higer than without lymph node metastasis[OR=0.26，95%CI（0.13，0.49），P＜0.01].The expression of FHIT in cancer was decreased significantly compared with normal group [OR=0.04，95%CI（0.02，0.09），P＜0.01] and adenoma group [OR=0.28，95%CI（0.18，0.41），P＜0.01]. The expression of FHIT in Dukes A+B stages was higer than Dukes C+D stages [OR=4.42，95%CI（2.95，6.64），P＜0.01]. The expression of FHIT in well-differentiated group was increased than poorly differentiated group [OR=4.53，95%CI（2.57，7.99），P＜0.01]. The expression of FHIT in tissue with lymph node metastasis was higer than without lymph node metastasis[OR=0.31，95%CI（0.18，0.52），P＜0.01]. Conclusion:Loss of PTEN and FHIT protein might play an important role in the development and progression of colorectal cancer, and was related to the malignant degree and clinical pathological characteristics of colorectal cancer. Detect the expression of PTEN and FHIT can be used for screening among high-risk population and early diagnosis of colorectal cancer, and estimating prognosis.