| Type infant wheezing bronchitis is a common and multiple disease of respiratorysystem in pediatrics, and virus infection is the most reason of the disease, afterinfected by the virus of children in the body can produce a large number ofinflammatory mediators and chemokines. The medium and the factors that can causeairway hyperresponsiveness, bronchospasm, increased airway resistance, etc. So thatthe children appear breathing, serious when even may induce the onset of asthma.There have been some research reports, about41%of the Wheezing bronchitischildren may develop into bronchial asthma in the future. So early intervention andtreatment for the wheezing bronchitis children has a vital significance. It not only canprevent the further of asthmatic bronchitis develop into bronchial asthma, but also canbenefit to children’s growth and development, improve the patient’s quality of life,reduce the burden of the family. The peripheral blood of25-(OH)D3effects onasthmatic disease pathogenesis is becoming a hot spot of research at present, but theresults don’t agree. In order to further understand the peripheral blood of25-(OH)D3effects on asthmatic disease pathogenesis, the experiment is designed. PurposeThrough infants of each group of asthmatic bronchitis, bronchial pneumonia andperipheral blood of normal infants25-(OH)D3, immunoglobulin IgE concentrationwas measured to investigate the peripheral blood of asthmatic bronchitis in children25-(OH)D3, IgE concentration level changes and analysis of the correlation of the two,discuss the two factors both in the pathogenesis of asthmatic bronchitis possible roleand their mutual relations, and thus for the children who repeated wheezing earlyintervening treatment provide new ideas and theoretical basis.Materials and methodsChoose the third affiliated hospital of zhengzhou university of pediatricrespiratory medicine ward hospitalized in October2012to April2013type wheezingbronchitis in children with a total of30cases, In line with the breathing typebronchitis diagnostic criteria, as asthma support group, the male21cases, female9cases,age was (1.5±0.30); Select the line with the same period of admission ofbronchial pneumonia diagnostic criteria of30cases of children,17males and13females, age was (1.9±0.25), as the pneumonia group;Another choice at the sametime in the third affiliated hospital of zhengzhou university of30cases of clinichealth department of health of infants and young children,19cases of male, female in11cases,age was (1.3±0.28),as the control group. Selection criteria: all choose tohospital on the day of the children did not use any drugs, all are born at term,all areless than or equal to3years old,except the chlidren who wheeze caused byrespiratory structures dysplasia, bronchopulmonary dysplasia, gastroesophagealreflux, respiratory tract, bronchial wheezing lymph node tuberculosis and otherdiseases,no fundamental heart and lung disease, and never use a glucocorticoid in thelast2weeks, normal control group of infants and young children without infectiousdisease in the last2weeks. Three groups of children on the age, gender, weight hadno significant difference, No statistical significance (P>0.05). And in the case of parents informed consent, and the permission of the hospital ethics committee andapproved.Extraction of three groups of children with peripheral venous blood2ml andcollect to vacuum by blood vessels, are drawn before medication. After collection thisperipheral venous blood, let them stand at room temperature for60min. Centrifugethe peripheral venous blood15minutes using a centrifugal3000r/min, then take tubeupper serum, and let it go EP tube,placement-80degrees cryopreservation. Thenapply enzyme-linked immunosorbent experiment method namely ELISA method todetect EP in the tube under test of serum25-(OH)D3, IgE concentration.Results1. Asthma support group of peripheral blood in25-(OH)D3has a lower level thanpneumonia group, significant difference, statistically significant (P<0.05);Pneumonia group of peripheral blood in25-(OH)D3level reduced compared withcontrol group, significant difference, statistically significant (P<0.05); Asthmasupport group of peripheral blood in25-(OH)D3level significantly lower than thecontrol group, significant difference, statistically significant (P<0.05).2. Asthma support group in peripheral blood IgE levels were significantly highercompared with pneumonia, significant difference, statistically significant(P<0.05); Pneumonia group in the peripheral blood IgE levels higher than thecontrol group is not obvious, there is no statistical significance (P>0.05); Asthmasupport group in the peripheral blood IgE levels higher than the control groupobviously, significant difference was statistically significant (P<0.05).3. Correlation analysis: Asthma support group, pneumonia group in the serum25-(OH)D3, IgE level negatively correlated, Control group serum25-(OH)D3, IgElevel has no relevance. Conclusions1.Lower peripheral blood vitamin D levels associated with the pathogenesis ofinfantile asthmatic diseases.2.Vitamin D deficiency can be stimulated by the IgE level increase the cause ofchildren with asthmatic diseases. |
PDF Full Text Request