To Explore The Role Of A Variety Of Inflammatory Mediators In Children With Asthmatic Diseases

Objective: Breathing is a common pediatric respiratory symptoms, isbreathing air flow rapidly through the narrow airway generated a high sound.Children with asthmatic disease refers to a group of respiratory syndromepresenting with symptoms of breathing, recurrent or the potentialcharacteristics of repeated attacks, including a variety of respiratory diseases,but mainly refers to the capillary bronchitis, asthmatic bronchitis, asthmaticpneumonia, infantile bronchial asthma and other respiratory diseases.Thisstudy by comparing children with asthmatic diseases and asthmatic acutelower respiratory tract infection and inflammation medium contrast research,analysis of CD62P, ECP, LTB4and allergic CRP in pediatric breathingdevelopment role, and to explore its clinical application value.Methods: Random choice between August2013and February2013inour hospital pediatric hospital treatment of asthmatic diseases in children with42cases, including17cases of children with acute capillary bronchitis,asthma bronchitis8cases,7cases with asthmatic pneumonia,10cases ofacute bronchial asthma;Without breathing40cases of children with lowerrespiratory tract infections, including28cases of acute bronchitis,bronchopneumonia in12cases;Random selection in our hospital pediatricclinic detection of trace elements of24cases of healthy children. UsingELISA method to detect each group with blood CD62P, ECP, LTB4andallergic CRP value, using SPSS13.0statistical software for statisticalcomparison analysis. Results:1.Asthmatic children with the serum level of CD62P（6.58±3.08ng/ml）was obviously higher than non asthmatic children with lower respiratory tractinfection level of CD62P（3.18±1.42ng/ml，P＜0.05and CD62P levels inchildren with healthy group（1.08±0.35ng/ml，P＜0.01）, non asthmaticchildren CD62P level （3.18±1.42ng/ml）higher than the healthy controlgroup（1.08±0.35ng/ml，P＜0.05, serum levels of CD62P difference hadstatistical significance.2.Asthmatic children (except for children with bronchial asthma) serumECP level（3.5±1.8ug/L） compared with non asthmatic children with lowerrespiratory tract infections ECP level（3.5±1.6ug/L，P＞0.05） has nostatistical significance.Which significantly higher with the serum ECP level（9.8±4.6ug/L）in children with bronchial asthma children with asthmaticchildren serum ECP level （3.5±1.6ug/L，P＜0.05）and health group ECPlevels （3.3±1.6ug/L，P＜0.05）compared with statistical significance.3.Asthmatic children with serum LTB4level （28.49±11.02pg/ml）obviously higher than that of non asthmatic children with lower respiratorytract infection children LTB4leve（l11.35±3.12pg/ml，P＜0.01） LTB4leveland health groups（0.85±0.11pg/ml，P＜0.01）, non asthmatic children LTB4level （11.35±3.12pg/ml）in serum LTB4level higher than the healthycontrols （0.85±0.11pg/ml， P＜0.01）, the difference had statisticalsignificance.4.Asthmatic children with serum hs-CRP level （6.52±2.43mg/L）andnon asthmatic children with lower respiratory tract infections hs-CRP level（6.43±2.34mg/L，P＞0.05） contrast has no statistical significance.But compared with healthy group of hs-CRP levels（3.35±1.24mg/L，P＜0.05）in children with statistical significance.Conclusion: In children with breathing occurs, serum CD62P, LTB4, hs-CRP were significantly elevated, ECP in children with acute asthma attackhas also increased significantly.Showed that CD62P, LTB4, hs-CRP and ECPwere involved in the pathological and physiological process of pediatricbreathing attack.