Volume Kinetics Of Acetate Ringer’s Solution And Hydroxyethyl Starch (130/0.4) Electrolyte Solution In The Early Fluid Resuscitation On Pig Hemorrhagic Shock

Objective: To study the Volume kinetics of acetate ringer’s solution andhydroxyethyl starch (130/0.4) electrolyte solution in the early fluid resuscitation Whenthe pig uncontrolled hemorrhagic shock.Methods: Twenty-four Obama mini pigs, In four groups at random.The group ofonly received acetate ringer’s solution(AR), The group of after shock received acetateringer’s solution(ARS), The group of only received hydroxyethyl starch (130/0.4)electrolyte solution(WH), The group of after shock received hydroxyethyl starch(130/0.4) electrolyte solution (WHS), AR only received acetate ringer’s solution with30ml/kg infusion in Central venous;WH only received hydroxyethyl starch (130/0.4)electrolyte solution with10ml/kg infusion in Central venous.ARS and WHS is adoptedto establish the model of uncontrolled hemorrhagic shock(HS) with capacity controlmethod in first, ARS received acetate ringer’s solution with30ml/kg infusion in Centralvenous and WHS received hydroxyethyl starch (130/0.4) electrolyte solution with10ml/kg infusion in Central venous. Each group collected arterial blood for blood gasanalysis every10min during the fluid infusion until after the infusion of120min,recordred blood cells deposited and (Hct)thehemoglobin (Hb);Uses the law of conservation ofmass analysis capacity of plasma, peripheral blood volume, the capacity of the dilutionrate and volume expansion efficiency. Application Matlab7.5software fitting out the time-dilution curve of single fluid space model and two fluid space model. andconsists of a chamber model equation for target volume (V) and clearance (Kr), by thesecond chamber model equation epicenter ventricular target capacity (V1), peripheraltarget capacity (V2), clearance (Kr) and the transfer coefficient (Kt) capacity of kineticparameters.Result:1、ARS and plasma capacity of WHS group was obviously lower thanthe control group (P <0.05); at the end of the infusion with60min to120min，plasma volume of WH group was obviously higher than the AR group, WHS groupobviously higher than the LRS group (P <0.05).2、 From the infusion is completed to120min after the infusion, The ARS expansion effect and the WHS group was higherthan the control group (P <0.05); volume expansion efficiency of the WH and theWHS group significantly greater than AR and ARS group (P <0.05).3、The infusionafter60min to120min，peripheral blood volume of ARS and WHS higher than thecontrol group (P <0.05), and ARS growth significantly; AR and ARS group wasobviously higher than that of WH and WHS group (P <0.05).4, in VOFS1parametersARS group compared with control group V and Kr has significantly decreased (P <0.05), while the WHS group Kr has decreased control group, but V is no change; WHand WHS group V and Kr significantly lower than that of AR and ARS group (P <0.05).5、 compared with the control group, V1and Kr ARS group was obviouslyreduced, the V2and Kt increased (P <0.05); Kr of WHS group was obviouslydecreased; WH group and Kt and Kr WHS group was obviously less than AR and ARSgroup (P <0.05).6、 and application of ICG method compared to measure plasmacapacity PV, AR group, WH group and ARS VOFS1(V) and VOFS2(V1+V2) werestatistically significant (P <0.05); With VOFS1(V) the comparison, AR group andARS VOFS2(V1+V2) increased (P <0.05); Therefore, AR and ARS group metVOFS2WH and WHS groups met VOFS1.Conclusion:1、When acetate ringer’s solution in pigs early fluid resuscitation, itis fit to VOFS2,offshoring its blood vessels increase, the plasma volumeunsteadiness.2、 When hydroxyethyl starch (130/0.4) electrolyte solution in pigs early fluid resuscitation,, it is fit to VOFS1,Offshoring its blood vessels is not obvious andplasma volume stability.3、Compared with hydroxyethyl starch (130/0.4) electrolytesolution,the acetate ringer’s solution in the early fluid resuscitation on pig hemorrhagicshock,the volume expansion efficiency increased.