Clinical Observation Of Contrast-induced Acute Kidney Injury After Percutaneous Coronary Intervention

Aim:To retrospective analyze the risk factors for contrast-induced acute kidney injury(CI-AKI) by evaluation of preoperative clinical indicators patients for percutaneous coronary intervention. We estimate and analyze the risk factors for contrast-induced acute kidney injury.Methods:We admit425PCI patients in cardiovascular department in the affiliated hospital of logistics university of Chinese people’s armed police force from January2012to January2013, comparing patients’ age, gender, hypertension, diabetes, blood lipid, renalfunction before and after the intervention, dosage of contrast agent and other clinical indicators. While we reject the patients with renal failure requiring dialysis and kidney transplants,pregnancy and lactation, allergy to contrast agents containing iodine, using non-steroidal anti-inflammatory drugs within48h, using nephrotoxicity drugs within1week, contact with contrast media in four weeks. We divided the patients into CI-AKI group and non-CI-AKI group based on the diagnostic criteria of CI-AKI, use single factor analysis and Logistic multifactor regression analysis of risk factors for CI-AKI.Results:1. By comparing the preoperative patients with postoperative of serum creatinine levels in425patients who undergo PCI, Determined in113cases of CI-AKI, rate of26.6%.divided the patients into the CI-AKI group and non-CI-AKI groups, Compared with the age, hypertension, diabetes, hyperlipidemia, no statistical differences (P>0.05); But the gender, left ventricular ejection fraction and History of chronic renal failure between two groups show significant statistical differences (P<0.05).2.Comparing the amount of contrast media in two groups, no statistical differences (P>0.05), CI-AKI group183.48±55.91ml, the non-CI-AKI group190.00±60.45ml.3. Multivariate logistic regression analysis:male, CRF history, preoperative Scr is the independent risk factors associated with CI-AKI disease excluded confounding factors, the relative risk from high to low was:men (OR=5.111), CRF disease (OR= 4.213), preoperative Scr (OR=2.995). Preoperative RBC (OR=0.084), EF value (OR value0.939) to reduce the protection factor in the pathogenesis of CI-AKI.Conclusion:History of chronic renal failure, Male, Serum Creatmne possible be the independent risk factors of contrast-induced acute kidney injury. Preoperative RBC, EF possible be the protective factors of contrast induced acute kidney injury.