| ObjectiveChildren who suffer from cerebral palsy have immature immune system, and their independent ability and active exercise are less than normal children, therefore, they are much easier to suffer from respiratory diseases, especially pneumonia. Because of the fundamental disease of cerebral palsy, children who combine with pneumonia have their own characteristics comparing to common children. The thoughts of holism, characteristics of syndrome differentiation in TCM and theoretical basis of treating different diseases with the same methods, afford the theoretical foundation for the treatment of cerebral palsy children with pneumonia. In the theory of TCM, blood stasis is not only the pathogenic factor, but also the pathogenic product, which always impacts the entire process of cerebral palsy and pneumonia that can be treated by the method of activating circulation to remove blood stasis. This study is to observe the curative effect by activating circulation to remove blood stasis in the treatment of cerebral palsy children with pneumonia, and provide new ideas and practical methods for the clinical treatment.Methods80cases of cerebral palsy children with pneumonia were treated in the women’s and children’s hospital of Nanhai District in Foshan, Guangdong Province, between2012January and2014January. With the method of the electronic computer random distribution,80cases were randomized into treatment group and control group, forty cases for each. Both groups were treated by western medicine, including anti-infective drugs, antipyretic, relieving cough, reducing sputum and oxygen therapy, etc. According to the children’s constitution, the treatment group would be treated by Chinese medicine injection with the effect of activating circulation to remove blood stasis for extra treatment. By clinical observation of seven days, the changes of PLT (Blood Platelet), APTT (Activated Partial Thromboplastin Time) and FIB (Fibrinogen) would be compared between the treatment group and control group.ResultsThe comparison of syndrome integral (fever, cough, phlegm, dyspnea and pulmonary rales) of pneumoniaComparing with syndromes integral of inter-group in the control group and the treatment group before and after treatment respectively, there were significant differences internally in the control group and the treatment group (P<0.05); and there were no significant differences in the first and third hospital day (P>0.05) and significant differences in the fifth and seventh hospital day between the control group and the treatment group (P<0.05).Shortened hospital daysThe average hospital days of the control group were11.60±3.71days; the average hospital days of the treatment group were8.93±2.39days. After inspection, the difference of the course between two groups was significant (P<0.05).Improved the curative efficacy (within seven days)The control group:seven cases were clinical cure, accounted for17.5%; fifteen cases were excellent effect, accounted for37.5%; eighteen cases were effective treatment, accounted for45%. The treatment group:seventeen cases were clinical cure, accounted for45%; seventeen cases were excellent effect, accounted for42.5%; six cases were effective treatment, accounted for15%. There were no loss cases in both groups. After testing, the curative efficacy between two groups was significant (P<0.05)Impact of PLT changesThe mean PLT of the control group in the first hospital day, the third day, the fifth day, the seventh day were336.9±139.41×10E9/L,329.15±103.81×10E9/L,336.83±102.36×10E9/L and375.85±117.10×10E9/L. After inspection, there were no statistic significances of changes of PLT between the first day and the third day, the first day and the fifth day, the first day and the seventh day of the control group (P>0.05).The mean PLT of the treatment group in the first hospital day, the third day, the fifth day, the seventh day were284.73±55.03×10E9/L,261.08±66.32×10E9/L,270.03±70.25×10E9/L and307.05±108.97×10E9/L. After inspection, there were statistic significances of changes of PLT between the first day and the third day, the first day and the fifth day of the treatment group (P<0.05), and no statistic significances of changes of PLT between the first day and the seventh day of the control group (P>0.05).Changes of PLT between the control group and the treatment group on the first day were not significant (P>0.05). Changes of PLT of the third day, the fifth day and the seventh days were significant (P<0.05).Impact of APTT changesThe mean APTT of the control group in the first hospital day and the seventh day were37.85±4.61s and39.72±4.12s. By analysis, changes of APTT between the first day and the seventh day were significant (P<0.05)The mean APTT of the treatment group in the first hospital day and the seventh day were37.03±3.57s and35.98±2.75s. By analysis, changes of APTT between the first day and the seventh day were significant (P<0.05).Changes of APTT between the control group and the treatment group on the first day were not significant (P>0.05). Changes of APTT of the seventh day were significant (P<0.05)Impact of FIB changesThe mean FIB of the control group in the first hospital day and the seventh day were2.86±0.48g/L and3.04±0.55g/L. By analysis, changes of FIB between the first day and the seventh day were significant (P<0.05).The mean FIB of the treatment group in the first hospital day and the seventh day were2.72±0.53g/L and2.61±0.46g/L. By analysis, changes of FIB between the first day and the seventh day were significant (P<0.05).Changes of FIB between the control group and the treatment group on the first day were not significant (P>0.05). Changes of FIB of the seventh days were significant (P<0.05).ConclusionBy using the method of activating circulation to remove blood stasis to treat cerebral palsy children with pneumonia, not only can improve the clinical efficacy, shorten the course of pneumonia, but also can impact the changes of PLT, APTT and FIB. With the improvement of clinical curative effect of pneumonia, when cerebral palsy children suffered from pneumonia, to some extent, it can not only promote the rehabilitation process of cerebral palsy, but also improve the rehabilitation efficacy of cerebral palsy. |
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