| Objectives:With advanced non-small cell lung cancer microwave ablation before treatment, after treatment,changes in the concentration of serum vascular endothelial growth factor (VEGF),and joint clinical efficacy of systemic chemotherapy.A preliminary study of vascular endothelial growth factor concentration is a poor prognostic factor for survival after microwave ablation.Methods:Choose20cases of healthy people as the control group,advanced non-small cell lung cancer40cases as a test group.Using double antibody sandwich ELISA method Measured healthy people and Advanced non-small cell lung cancer before micro-wave ablation,ablation after the first seven days of serum vascular endothelial grow-th factor (VEGF) concentration,The advanced non-small cell lung cancer patients after treatment MWA divided into two groups (microwave combination chemother-apy group) and control group (simple microwave group),observation group received systemic chemotherapy at day7after ablation,chemotherapy regimens:Gemcitabine1000mg/m2dl,8or Docetaxel plus Cisplatin75mg/m2dl75mg/m2dl-3,q21w,at least4cycles of chemotherapy.Determination of serum VEGF observation group after four cycles of chemotherapy in the end,VEGF concentration was measured in the control group after three months in a microwave ablation.Respectively,were observed in patients with recent efficiency,disease control rate and long-term survival.Results:After a double-antibody sandwich ELISA assay healthy human serum VEGF levels were significantly lower in patients with advanced NSCLC,both statistically significant(P<0.05).Before and after the first seven days of microwave ablation serum VEGF levels higher than ablation,and the difference was statistically signifi-cant(P<0.05).Observation group were combined4cycles of systemic serum VEGF levels and control group underwent microwave ablation differences in serum VEGF levels after chemotherapy in March after no statistically significant(P>0.05).Term effect:all patients in both groups did not reach complete remission(CR), eight cases of the observation group achieved partial remission(PR),9had stable dis-ease(SD),5patients with advanced(PD),efficiency(RR)36.4%(8/22),disease control rate was77.3%(17/22),the control group five cases of partial remission(PR),3had stable disease(SD),10patients with advanced(PD),efficiency(RR)27.8%(5/18),dise-ase control rate was44.4%(8/18).There is no comparison between the two sets of efficiency(RR) was a significant difference(X2=0.33,P>0.05);There were significant differences (X2=4.55,P<0.05) groups disease control rate.Long-term survival:no significant difference between the study group and the control group,1-year survival rate(P>0.05),2-year survival rate was statistically sign-ificant differences(P<0.05).Conclusion:1. Microwave ablation treatment of advanced NSCLC have minimally invasive, efficient, safe and side effects of small advantage.2.Non-small cell lung cancer patients was significantly higher than the serum VEGF concentration in healthy volunteers.3.Microwave patients with non-small cell lung cancer after ablation compared with pre-treatment serum VEGF levels increased, and the difference was statistically significant between the presence.4.Ablation combined with systemic chemotherapy can reduce ablation elevated serum levels of VEGF5.After three months of microwave ablation, ablation of serum VEGF levels returned to the level before.6.Microwave ablation therapy combined with chemotherapy may be more than simply a microwave effective control of disease progression and prolong survival of patients... |
