Bone Mass Density, Vitamin D And Biomarkers Of Bone Turnover In Idiopathic Benign Paroxysmal Positional Vertigo

Objective: The aim of this study was to identify bone metabolism inpatients with benign paroxysmal positional vertigo (BPPV) and to furtherinvestigate the possible mechanism of BPPV.Methods: A total of40patients (26women and14men, mean age±SD=51.9±10.8) with idiopathic BPPV, as well as30control subjects (19women and11men, mean age±SD=47.8±10.4), participated in thestudy. The results of Dual-energy x-ray absorptiometry scan results werecompared and analyzed, along with serum levels of vitamin D, N-terminalmidfragment（N-MID）, β-collagen cross-linked C-telopeptide（β-CTX），bone alkaline phosphatase（BALP）.Results: The prevalences of osteopenia and osteoporosis in womenover48years old with BPPV were higher than in controls（P<0.05）.Therewere no diffrence between BPPV subjects and controls either in vitaminD,BALP,N-MID or in β-CTX levels.Conclusions: Osteopenia/osteoporosis may be associated withidiopathic benign paroxysmal positional vertigo in women over48years old. There’s no correlation between idiopathic benign paroxysmalpositional vertigo and bone turnover markers.