Meta-analysis Of The Association Studies Of Tumor Necrosis Factor-B+252A/G Genetic Polymorphisms With Gastric Cancer Susceptibility

Objective: Tumor necrosis factor-β (TNF-β)+252A/G geneticpolymorphism may be a risk factor for gastric cancer. To confirm theconnection between the two by means of meta-analysis.Methods: Case-control studies about TNF-β+252A/G geneticpolymorphism and morbidity of gastric cancer were collected fromPubMed, Ovid, Springer, CBM, CNKI and Wan fang Databases betweenestablishment and June2013. Based on the tailor-made criteria forpublications, the related studies were incorporated through cautious search.The research was conducted by applying Review Manager5.2and Stata12.0software with stability being evaluated by both stratified analysis andsensitivity analysis. Moreover, Begg’s funnel plot and Egger’s regressionwere used to assess the published bias of articles.Results: Sixteen case-control studies contain2538cases and3908controls. Meta-analysis showed that in each genetic model, no significantdifference was found in the correlation between TNF-β+252A/G genetic polymorphism and gastric cancer: codominant genetic model (G/Gvs.A/A):OR and95%CI:0.95(0.76,1.20); dominant genetic model[(A/G+G/G) vs. A/A]: OR and95%CI:1.09(0.91,1.32); recessive geneticmodel [G/G vs.(A/G+A/A)]:OR and95%CI:0.88(0.72,1.07); allelegenetic model (G vs. A):OR and95%CI:1.00(0.90,1.11).(G/G,G/A,A/Arespectively represent the genotype).There was no statistical significance inracial subgroup analysis.Conclusion: Our results indicate that TNF-β+252A/G geneticpolymorphisms are not associated with gastric cancer risk. The conclusionis limited by the quality and number of included studies. Large-scaleresearches are need in the further.