The Clinical Research Of Intravitreal Ranibizumab Injection In The Treatment Of Choroid Neovascularization

Objective: To compare the clinical effect of intravitreal ranibizumab injection andphotodynamic therapy(photodynamic therapy,PDT) on choroid neovascularization.Methods:42cases patients with choroid neovascularization were chosed in eye clinicin our hospital from February2011to February2013.All cases diagnosed by fundusexamination, fluorescein fundus angiography, indocyanine green angiography(FFA&ICGA) and optical coherence tomography (OCT) were random ly dividedinto two groups, the22cases patients with intravitreal ranibizumab injection wasgroup A, once a month, continuous injection3times in all,the20cases patients withphotodynamic therapy treatment was group B, treated1time,regularly review aftertreatment at1month,3months,6months,12months,if the disease progression orrecurrence, according to the progression of disease treated with intravitrealranibizumab injection or photodynamic therapy again.Statistics and analysis the twogroups’ best corrected visual acuity (BCVA) leakage area and central foveal thickness(CFT) before and after treatment, compared the clinical effects of two groups.Results:2cases in group A was treated with intravitreal ranibizumab injection againafter3months because of fundus hemorrhage,3cases in group B was treated withphotodynamic therapy again after6months because of vision loss increasely.BCVA:Both group A and group B’s best corrected visual acuity after treatment haveimproved, two groups had no statistically significant difference After1month oftherapy (P>0.05), After3months,6months and12months, the best corrected visualacuity of group A improved more obviously than group B,it had statisticallysignificant difference (P<0.05), the visual acuity of group A improved moreobviously than group B for occult choroidal neovascularization, two groups hadstatistically significant difference(P<0.05), two groups had no statistically significantdifference for typical choroidal neovascularization (P>0.05); Leakage area: Thefundus hemorrhage of two groups was absorbed after treatment,retinal edema、 exudation and leakage area had disappeared or reduction,Two kinds of treatmentmethods in reducing leakage of fluorescein had no statistically significant difference(P>0.05); CFT:The average central foveal thickness of two groups aftertreatment were thinner compared with therapy before, there wasstatistically significant difference(P<0.05), two kinds of treatment methods inreducing central fovea edema of macula had no statistically significant difference at1month,3month,6month and12month after therapy (P>0.05).Conclusion:1. Intravitreal ranibizumab injection and photodynamic therapy areeffective methods in the treatment of CNV, both can improve visualfunction,stability fluorescein leakage and reduce the central fovea edema ofmacula.2. Intravitreal ranibizumab injection in the treatment of occult choroidalneovascularization is better than PDT treatment in the improvement of patients’visual function,two methods in the treatment of typical choroidalneovascularization had no statistically significant difference.3Two kinds of treatment methods in reducing leakage of fluorescein, central foveaedema of macular had no statistically significant difference in the short term,stillneed further clinical test.