| Objective: To test the hypothesis whether the transient receptorpotential vanilloid type1has protective effect in inflammatory response ofpost-myocardial infarction.Methods:40patients were recruited in this study according to theclinical diagnoses and the results of coronary arteriography. They wereselected into four groups: normal group(no diabetes mellitus nor coronaryarteriography negative, n=10), DM group(coronary arteriography negativewith diabetes mellitus, n=10), MI group(myocardial infarction withoutdiabetes mellitus, n=10), MI+DM group(myocardial infarction withdiabetes mellitus, n=10). plasma levels of TNF-α(tumour necrosis factor-α),IL-6(interleukin-6), MCP-1(monocyte-chemoattractant-protein-1) weremeasured(determined by ELISA). The mRNA expressions of TRPV1inneutrophilic granulocytes were detected by RT-qPCR.Results: The mRNA expressions of TRPV1can be detected inneutrophilic granulocytes. The mRNA expressions of TRPV1in DM groupand MI+DM group were both lower than normal group(p<0.05). The inflammatory cytokines increased in post-myocardial infarction. The levelsof TNF-α in MI+DM group were higher comparing with MIgroup(p<0.05).Conclusions: the patients with diabetes mellitus had lower mRNAexpressions of TRPV1in neutrophilic granulocytes. In addition, thepatients with diabetes mellitus had severer inflammatory responses aftermyocardial infarction. This study indicate that TRPV1may have theprotective effect in inflammatory response of post-myocardial infarction. |
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