Expression And Prognosis Of Golgi Glycoprotein73and Secreted Clusterin In Hepatocellular Carcinoma

Objective:To investigate the expression of GP73and sCLU in HCC and their relationship with the clinicopathological features and the prognosis.Methods:75cases of hepatocellular carcinoma were collected. Immunohistochemistry was used to determine the expression of GP73and sCLU in HCC and normal liver tissues. Spearman rank were used to analyse the correlation between GP73and sCLU in HCC. Investigate their relationship with the clinicopathological features and the prognosis.Results：The expression of GP73and sCLU in75HCC patients were different from those in normal liver tissues (p<0.05).GP73positively correlated with the sCLU in HCC (r=0.405, p<0.05). GP73and sCLU were associated with clinicopathological features including tumor differentiation, TNM stage and vascular invasion (p<0.05); GP73and sCLU had no correlation with the patient’s gender,age,HBsAg,cirrhosis, AFP value, portal vein thrombosis and tumor numbers (p>0.05). GP73associated with survival but not sCLU.Conclusion:GP73and sCLU have a higher positive rate in HCC and GP73positively correlated with the sCLU. The expression of GP73and sCLU are probably closely related with the invasion of HCC, which can help evaluate the prognosis of the patients.