Role Of P504S And Gleason Scores In Prostate Cancer Patients With Bone Metastasis

Objective:To investigate the correlation between bone metastases in patients with prostate cancer and P504S expression, Gleason score. Methods:From July2012to June2013,58patients with prostate cancer were collected in our hospital, in which32with bone metastasis and26without bone metastasis. P504S expression in tissue of prostate cancer were measured using immunohistochemical two-steping of En Vision, All of patients underwent whole body radionuclide bone scan. The role of P504S and Gleason score in bone metastasis were analyzed. Results:For prostate cancer with bone metastasis, P504S expression was strength, correlation coefficients were0.818, there are statistically significant differences (P<0.05); correlation coefficient with the Gleason scores was0.474, P<0.007. By rank and inspection analysis in groups and no bone metastases of bone metastases, P504S expression difference was statistically significant (Z=4.110, P0.001), the rank and inspection analysis of bone metastases group and no group of bone metastases of Gleason score, difference was statistically significant (Z=3.372, P=3.372). Conclusions:High expression of P504S in prostate cancer patients might be used as a biomarker for bone metastasis in patient with prostate cancer as well as a sensitive indicator of prognosis.