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Diabetic Retinopathy,Serum OX-LDL In Patients With Lesions LPa Expression For The Early Diagnosis Of Diabetic Retinopathy

Posted on:2015-03-07Degree:MasterType:Thesis
Country:ChinaCandidate:Y L ZhouFull Text:PDF
GTID:2284330434965960Subject:Ophthalmology
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Objective:To determine the relevant blood parameters observed in type2diabetic retinopathy patients hospitalized for various departments of our hospital and its significance for the early diagnosis of diabetic retinopathy. Diabetic retinopathy combined to provide early prevention and control of new ideas. Methods:2012April-August relevant departments in our hospital for treatment of type2diabetes patients with fundus fluorescein angiography (FFA) or fundus photography checks. Select qualified142diabetic patients a comprehensive eye examination, record history, systemic complications and so on. Divided into three groups, respectively, for the simple diabetes(NDR,55cases) group, non-proliferative diabetic retinopathy(NPDR,67cases) group, proliferative diabetic retinopathy(PDR,20cases)group.OX-LDLwas measuredby enzyme-linked immunosorbent assay (ELISA). Using immune turbidimetric assay LPa. At the same time, fasting plasma (FBG) and postprandial glucose (2hPG). Glycated hemoglobin, HDL,LDL,ApoB, glycated serum protein,24-hour urinary catheter urine albumin levels. Spss20.0data using statistical analysis software. Results:(1) NDR group, NPDR group, PDR group of three groups:the course of time, urine albumin, lipoprotein a(LPa),oxidized low-density lipoprotein (OX-LDL), the time history of hypertension, blood urea nitrogen, creatinine, the difference was statistically significant levels (P<0.05).(2)Logistic regression analysis showed that:the course of time, urine albumin, LPa with diabetic retinopathy (DR) occurs correlated the results with statistical significance (P<0.05). ConclusionrThe time duration of diabetes, blood pressure, blood urea nitrogen, urinary albumin, lipoprotein a (LPa) level to a certain extent can be used as predictors of DR is happening. Which course, microalbuminuria,LPa,is an independent risk factor for the onset of DR,DR lay the foundation for the prevention of the occurrence and development of clinical treatment program as soon as possible.
Keywords/Search Tags:diabetic retinopathy, oxidized low-density lipoprotein, lipoprotein a, risk factors, early prediction
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