The Comparison Of Immunogenicity And Safety Of Cervarix And Gardasil: A Meta Analysis

Objective: Assess the comparison of immunogenicity of Cervarix and Gardasil inorder to discuss the effectiveness and application value of the HPV vaccine.Methods: By searching the Cochrane library、Pubmed、Clinicaltrial、EMBSASE etal,Supplemented by manual retrieval, and use the search on the internet query literature,the combination of tracing reference or reference integrated retrievalmethods,included the randomized controlled trials(RCTs) about the immunogenicityof Cervarix and Gardasil.Two authors independently reviewed the data and assessedthe quality.The data were input and analyed by Revman4.2software.Result: Three randomized controlled trials involving1396cases met the inclusioncriteria, all cases input is inoculated Cervarix or Gardasil. In one studies,Cervarix isinoculated in the time of0、1、6month,Gardasil is inoculated in the time of0、2、6month, in two study,Cervarix and Gadarsil is inoculated in the time of0、1.5、6month or0、1、6month.The meta analysis showed that1、7months after inoculation,the HPV16antibody positive rate of Cervarix is no statistical significance comparedto Gardasil(RR=0.99,95%CI(0.95-1.04),Z=0.33,P=0.74>0.05), forest figure locatedon the vertical line;2、7months after inoculation, the HPV18antibody positive rate ofCervarix is no statistical significance compared to Gardasil(RR=0.99,95%CI(0.95-1.04),Z=0.33,P=0.74>0.05), forest figure located on the vertical line；3、7months afterinoculation, the geometric mean antibody titer of Cervarix group is statisticallysignificant compared to Gardasil(WMD=0.51,95%CI(0.44-0.58),Z=14.26,P<0.00001), forest figure located on the right side in the vertical line；4、7months afterinoculation, the geometric mean antibody titer of Cervarix group is statisticallysignificant compared to Gardasil(WMD=0.80,95%CI(0.62-0.98),Z=8.60,P<0.00001),forest figure located in the vertical line on the right side.5、The data of safety of the input study is not enough, but the imformation of two study indicate that the adversereaction of Cervarix is higher than Gadarsil.Conclusion: In terms of antibody positive rate, the immunogenicity of Gardasil andCervarix can be thought of be no major difference; In terms of geometric meanantibody titer, we can think that the immunogenicity of Cervarix is higher thanGardasil7months after inoculation; In terms of safety, two vaccines is both safe, theadverse reaction of Cervarix is a little higher than Gadarsil. In general, Gardasil andCervarix have good immunogenicity, Cervarix is higher than Gardasil in immunoge-nicity in terms of geometric mean antibody titer, the HPV vaccines have good clinicalapplication value and certain effectiveness, but how the Health economics of the twovaccines is unkown.We are looking forward to more stringent, randomized,double-blind, controlled trials provide high quality evidence in the future.