Study On Relationship Of Serum Ferritin With Diabetic Peripheral Neuropathy And Nerve Conduction Velocity

Objective To investigate the clinical features of serum ferritin and nerve conductionvelocity in patients with diabetic peripheral neuropathy, provide a theoretical basis for theprevention and treatment of diabetic peripheral neuropathy.Methods According to WHO standards of diagnosis and classification of diabetesmellitus (1999), Hebei United University Hospital Department of Endocrinology selected90cases of T2DM patients from February2013to November2013, including55malesand35females, the age range of21to78years, mean age55.20±10.98years.Accordingto the EMG findings, patients were divided into two groups, the DM group20patients (12males and8females, age range21to66years, mean age48.70±14.13years),70cases ofT2DM DPN group (male43cases,27females, age range21to78years, mean age55.51±10.74years). Graduate study filled in the questionnaire about age, gender, disease duration,symptoms. All the subject on an empty stomach for more than12hours, no alcohol24hours after early morning pump elbow5ml venous blood immediately laboratory detectionof fasting plasma glucose (FPG), serum total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C),glycosylated hemoglobin (HbA1c), folic acid (FA), vitamin B12(VitB12), serum ferritinlevels (SF).All the data was analyzed by statistical software package SPSS19.0, Thenormal distribution of the measure information are expressed as mean±standard deviation（x±s）,two sets of comparison groups use t test. Counting information are expressed aspercent, comparing use chi-squared2test.Between multiple sets of data were comparedusing ANOVA. Linear correlation between the indicators, analyze and calculate thecorrelation coefficient. Multivariate Logistic regression was used to analysis of risk factorsfor DPN. Test standard: P<0.05statistical significant, P<0.01indicates statisticallysignificant results.Results1Through χ2analysis, the gender constitution of the patients with DPN had nostatistical difference with the diabetic group. Comparison of the age of patients betweenDPN groups and the diabetic group was not statistically significant (P>0.05). Comparisonof T2DM duration, DPN group was higher than the diabetic group, the difference wasstatistically significant (P<0.05). Comparison of BMI of patients with T2DM betweenDPN groups and the diabetic group was not statistically significant (P>0.05).2The groupof patients with DPN HbA1C, TG, TC and LDL-C was higher than the diabetic group,HDL-C, FA and VitB12lower than diabetic group, the difference was statisticallysignificant (P<0.05).3Compared with the levels of SF between DPN group and DM group,DPN group was higher than DM group, the difference was statistically significant (P<0.05). 4There are two cases of patients with SF>400ng/ml in DM group,25cases in DPN group.Analysised by χ2test OR=5.000, it indicated that when the SF above the normal range,diabetes increases the risk of the occurrence of DPN5double.5Pearson correlationanalysis was carried out to analyzed the relationship between SF and Gender, age, duration,BMI, systolic blood pressure, diastolic blood pressure, FPG, HbA1C, TG, TC, LDL-C,HDL-C, FA and VitB12. SF has positive correlation with duration, BMI, systolic bloodpressure, diastolic blood pressure, FPG, HbA1C, TG, TC, LDL-C (r=0.73,0.32,0.32,0.19,0.18,0.67,0.49,0.51,0.75, P<0.05), and has negative correlation with HDL-C, FA,VitB12(r=-0.61,-0.78,-0.53, P<0.05), and no correlation with gender, age (r=0.11,0.17,P>0.05).6Compared with NCV between DPN group and DM group, median nerve, ulnarnerve, tibial nerve, peroneal nerve MCV and median nerve, ulnar nerve, sural nerve SCVslowed significantly in DPN group, and the difference was statistically significant (P<0.05).7The diabetic patients were divided in to four groups by quartile of SF levels from low tohigh. With SF levels increasing, nerve conduction velocity slowed significantly, thedifference between these groups was statistically significant (P<0.05).8In a merger of theDPN as the dependent variable, line diabetics multivariate Logistic regression analysisshowed that DPN has positive correlation with duration, HbA1C, ferritin, LDL-C (P<0.05),and no correlation with the rest (P>0.05).Conclusions1Levels of SF in patients with DPN are higher than in diabetic patients.2.There is a negative correlation between SF and nerve conduction velocity.3SF haspositive correlation with duration, BMI, systolic blood pressure, diastolic blood pressure,FPG, HbA1C, TG, TC, LDL-C, and negative correlation with HDL-C, FA and VitB12.