The Level Of Serum Platelet Aggregation Rate Of Diabetic Patients And Its Relationship With Peripheral Nerve Conduction Velocity

Objective: to observe the level of serum platelet aggregation rate of diabetic patientsand non-diabetic patients in endocrinology department of Fujian Provincial hospitaland to analyze its correlation with diabetic peripheral nerve conduction velocity.Methods:67patients with diabetes collected in endocrinology department of ourhospital were divided into A, B two groups. patients in group A did not receiveanti-platelet therapy prior to admission, while those in Group B received aspirin andClopidogrel treatment more than a month prior to admission。examining glcosylatedhemoglobin, platelet aggregation rate and peripheral nerve conduction velocity ofeach patient。 Another20patients without diabetes mellitus were collected inendocrinology department of our hospital as group C, examining rate of plateletaggregation. Finally，the data was analyzed by Statistical methods.Results: the levelof serum platelet aggregation rate between group A and B were different, which wasstatistically significant. Group A and group C get the same result, while that betweengroup B and group C showed no statistically significance. The Peripheral nerveconduction velocity among group A and group B showed statistical significance.Conclusion: the level of serum platelet aggregation rate of patients with diabetic washigher than that without diabetic. The higher serum platelet aggregation rate indiabetic patients, the more serious of the peripheral nerve damage and the slowerperipheral nerve conduction velocity. Combined use of aspirin and clopidogrel caneffectively reduce the serum platelet aggregation rate of diabetic patients so as toimprove peripheral nerve conduction velocity, which played a positive role on treatingdiabetic peripheral neuropathy.