The Studies On The Association Of Fibrinogen And Carotid Atherosclerosis With Recurrent Cerebral Infarction

Objective Detect the association of fibrinogen and carotid plaquewith recurrent cerebral infarction.Metheds Selected300cases of patients with cerebral infarction inthe Department of Neurology of Gansu Provincial People’s Hospital fromJanuary2011to May2013, those cases were analyzed retrospectively andregarded as the recurrence group (group A), divided them into threegroups by the size of recurrence infarction lesions. The first groupwas a large area of recurrence infarction lesions (group A1,138cases),the second group was a small area of recurrence infarctionlesions (group A2,120patients) and The third group was lacunarinfarction lesions (group A3,42cases). Divided into3group byneurological deficit scores of China Stroke Scale in the same way, theywere heavy group (group A①,39cases), medium group (group A②,142cases), light group (group A③,119cases). Selected another52casesof patients with first cerebral infarction at the same period in thehospital as first group (group B). Recorded352patients’age, gender,plasma fibrinogen values measured within24hours of Blood tests, lipidlevel and neurological deficit scores by China Stroke Scale, while recorded all patients’ past medical history (hypertension, diabetes,hyperlipidemia) in detail. Using carotid artery color dopplerultrasound (CDUS) to detect carotid artery,observing the presence orabsence of carotid artery plaque and got the information of those existedplaques’quantity and echogenicity. Analyzed the date statistically bySPSS17.0software, obtained the results.Results (1) First cerebral infarction and recurrent cerebralinfarction were common in males and old people, The prevalence of ofdiabetes, hypertension and hyperlipidemia were high in the two groups.Group A compared with group B in the age of onset, diabetes,hypertension, high cholesterol FIB, CSS score,the results werestatistically significant (P<0.05).(2) Mixed plaques and multipleplaques were the most commonly in group A and group B. In the comparisonof carotid plaques’ stability and quantity between group A and groupB, the results were no difference statistically in comparison of hardand soft plaques (P=0.076>0.050), but were statistically significantin mixed plaques (P=0.001<0.05), were no significant difference incomparison of soft plaque (P=0.0859>0.05). Group A compared with groupB in the multiple plaques’ incidence was statistically significant(P=0.007<0.05).(3) The large area of recurrence infarction lesionsgroup (group A1)，the patients’fibrinogen average level was3.55±0.90g/L; the small area of recurrence infarction lesions group(group A2),the patients’ fibrinogen average level was3.33±0.77g/L;the lacunar recurrence infarction lesions group (group A3),thepatients’ fibrinogen average level of fibrinogen was3.10±0.79g/L. The plasma fibrinogen levels in group A1,A2andA3were higher than thosein group B, the comparison of group A1and group B or group A2and groupB in the plasma FIB level,the results were statistically significant(P<0.05), group A1and group A2compared with group A3in the plasma FIBlevel were statistically significant (P <0.05).Group A1、A2、A3were mixedplaques and multiple plaques commonly. In the comparison of plaques’stability and quantity among the three groups, only group A1and groupA2has differences in the comparison of multiple plaques’ incidence,the another two groups were no significantly difference (P>0.05).(4)The comparison of the plasma FIB level in Heavy group (group A①), Mediumgroup (group A②) and Light group (group A③), group A①compared withgroup A②and group A③,the results were statistically significant(P<0.05), group A②compared with group A③, the results were notstatistically significant (P=0.097>0.05). Three groups were mixedplaques and multiple plaques commonly. In the comparison of plaques’stability and quantity among those three groups, the results were notstatistically significant (P>0.05).Conclusion1. Diabetes, hypertension, high cholesterol, highfibrinogen level， mixed plaques, multiple plaques had relationshipwith recurrent cerebral infarction.2.Plasma fibrinogen be amonitoring indicators of the size of recurrence infarction lesions.FIBlevels had relationship with the severity of recurrent cerebralinfarction, can be a monitoring indicators of the severity of recurrentcerebral infarction.3The incidence of mixed plaques and multipleplaques were the higest plaques in recurrence cerebral infarction. carotid plaque’s stability and quantity in recurrent infarction hadno effect on monitoring the size of recurrence infarction lesions orthe severity of recurrent cerebral infarction.