Comparing The Changes Of Cerebral Blood Flow And Intracranial Pressure During Laparoscopic Gynecologic Surgery Under Propofol And Etomidate Total Intravenous Anesthesia

Objective: To research and campare the changes in situation of cerebral blood flow and intracranial pressure during laparoscopic gynecologic surgery performed under propofol and etomidate total intravenous anesthesia.Methods: Fourty gynecologic patients(ASAI~II) were randamly divided into two groups(n=20 each):group I and group II. Anesthesia was induced with TCI of propofol in group II, and etomidate in group I via total intravenous anesthesia. Middle cerebral arterial systolic velocity(Vs) and pulsatility index(PI) detected by transcranial doppler ultrasound were recorded at 5 min after supine position(T1), and tracheal tube was being inserted(T2), 5 min after tracheal intubation(T3), immediately and 15 min after abdominal CO2 insufflation in trendelenburg lithotany position(T4 and T5), while at 5 min after deflation of abdomen and supine position(T6).Results:1 Compared with group II, Vs and PI were significantly increased at T3,T4,T5 in group I(P<0.05).2 Compared with T1, Vs and PI were significantly decreased at T3 in group II(P<0.05), Vs and PI were significantly increased at T4,T5 in group I(P<0.05).Conclusion: Compared with etomidate, propofol total intravenous anesthesia has minor impact on cerebral blood flow and intracranial pressure during laparoscopic gynecologic surgery.