Expression And Significance Of IL-24 And HLA-G In Maternal Serum And Placental Tissue Of Preeclampsia

Objective:To explore the expressions and significance of IL-24 and HLA-G in serum and placenta of patients with preeclampsia. Help to reveal the pathogenesis of preeclampsia, screening, diagnosis and treatment for the disease to provide the experimental basis and new ideas.Methods:Choose between January 2013 and January 2014 in the First Affiliated Hospital of Guangxi Medical University, including 20 cases mild preeclampsia,15 cases of severe preeclampsia; At the same period, randomly selected 30 cases of normal pregnant women as the control group. Compare they are clinical feature. ELISA and immunohistochemical SP methods were used to detect the expression levels of IL-24 and HLA-G in maternal serum and placenta.Results:Compared with control group, the expression level of IL-24 in serum of preeclampsia group increased significantly (P<0.05), the expression level of HLA-G decreased significantly (P<0.05). They were (113.81±13.77) pg/ml vs.(23.23±3.27) U/ml,(82.21±11.05) pg/ml vs.(34.78±3.77) U/ml. The level of serum IL-24 was positively correlated with the severity of preeclampsia (r= 0.857, P<0.05); There was a negative correlation between serum HLA-G protein level and the severity of preeclampsia (r=-0.858, P< 0.05); There was a negative correlation between IL-24 and HLA-G expression in serum (r=-0.976,P<0.05).The positive expression rate of IL-24 in placenta tissue of preeclampsia group was statistically significantly higher than that in control group (P<0.05), they were 8%,71% and 96%,while the positive expression rates of HLA-G in placenta tissue of preeclampsia group was statistically significantly lower than that in control group (P<0.05), they were 99%,86% and 66%.Conclusions:IL-24 and HLA-G may be involved in occurrence and pathogenesis of preeclampsia.