Effect Of Mild Hypothermia On The Coagulation With Traumatic Haemorrhagic Shock In Rabbits

Objective To investigate the mild hypothermia effect on coagulation in the New Zealand rabbits subjected to traumatic and hymorrhagic shock in this experiment.Methods 20 rabbits were randomly divided into two groups of ten animals each: sham control and mild hypothermia (group H),traumatic hymorrhagic shock and mild hypothermia (group T/HS). Hypothermia was induced by anesthesia induction, with a cold blanket and ice bag. Hemorrhage was induced by bleeding 35% of total blood volume. Capacity for coagulation was measured by thromboelastometry(TEG) at different time including before shock(to),30 minutes after shock(t1),2 hours after hypothermia(t2),2 hour after resuscitation and warming (t3).Results (1) Baseline parameters were not significantly different amongst the groups. (2) In group T/HS,the initial clotting Time(r) and the maximum amplitude(MA) were reduced compared with group T/H at 30 minutes after shock (all P<0.05),and maximum amplitude(MA) was reduced compared with group T/H during 2 hours after hypothermia,2 hour after resuscitation and warming (P<0.05),the clotformation time(K) was no significantly difference in 30 minutes after shock,2 hours after hypothermia,2 hour after resuscitation and warming (all P>0.05). (3) Two groups of the rate of clot formation(Angle),the coagulationindex(CI) did not change significantly compared with before shock,30 minutes after shock,2 hours after hypothermia,2 hour after resuscitation and warming (all P>0.05).Conclusion (1) Mild hypothermia does not significantly effect on the holistic coagulation system in our model.(2) Based on the results of the present study we suggest that mild hypothermia can be safely performed after stabilization following the earliest traumatic haemorrhagic shock in rabbits.