| Objective Related factors of 1-hour plasma glucose(1-h PG) levels after 75-gram oral glucose tolerance test(75-g OGTT)in normal glucose tolerance groups have been analysed for the purpose of providing more evidence for theprevention and control of diabetes.Methods With the method of cluster sampling and cross-sectional survey,from April 2012 to December 2012, health examination was performed in 9986 iindividualsin four communities of Hefei,Anhui province,who were older than 40 and The han Chinese residents.All subjects without diabetics were conducted the 75-gOGTT test. According to the results of 75-g OGTT test,all the 5,709 people with normal glucose tolerance were divided into two groups:2917 subjects in NGT-1 group with1-h PG≥8.6 mmol/L while 2792 subjects in NGT-2 group with1-hPG<8.6 mmol/L. All the subjects accepted the questionnaire survey including age, gender, height, weight,waist circumference, waist-hip ratio,systolic and diastolic pressure, the daily consumption of fruits, vegetable sand meat,the history of smoking,sports,drinking,coronary heart disease and so on. The blood biochemical tests of fasting plasma-glucose(FPG),1-h PG,2-h PG,hemoglobin A1c(HbA1c),alanine aminotransferase(ALT),Aspart ate aminotransferase(AST) and γ- glutamine transaminase(γ-GT) were also performed.The clinical features of the two groups were compared, and each factor’s contributionto the level of 1-h PG of subjects with normal glucose tolerancewas determined by multivaritate wasdeterminedby multivariate logistic regression.Results (1)In this survey population,between NGT1 groups and NGT2 group, body mass index(BMI), waist circumference, waist-hip ratio(WHR) were not significantly different(P> 0.05), but the self-report rate of coronary heart disease were increasedin NGT2 group。(2)Compared with NGT2 group, the age,SBP, DBP, FPG, 1-h PG, 2-h PG, HbA1 C, TC, TG, LDL-c,e-GFR,ALT, AST, γ-GT,andMS in NGT1 group were increased(P <0.05), while HDL-c was decreased(P <0.05),and all the differences were statistically significant.(3)The levels of 1-h PG in male are higher than that in female,the difference was statistically significant(8.79 ± 1.97 vs8.63 ± 1.97, P <0.05);stratified according to the age of every 10 years old, it was found that there are synchronous increasing trend in1-h PG levels and age, especially inpeople<60-year-old the trend was more pronounced(P <0.05). In addition, the average levels of 1-h PG are higher in people older than60 years(P <0.05).( 4) Compared with normotensive population, 1-h PG levels wasincreased in people with hypertension, the difference was statistically significant(P <0.05).(5)Compared with subjects with normal blood lipid,the 1-h PG levels were increased in isolated higher TC group, isolated higher TG group,higher TC plush the TG group,andisolated high LDL levels group, the differences were statistically significant(P <0.05), 1-h PG levelshad no significant differencesbetween isolated lower HDL- c group and normal blood lipid group(P> 0.05). Amongall kinds of hyperlipidemic groups,the isolated higher TG grouphas thehighest 1-h PG level, but the differenceswere not statistically significant(P> 0.05)(6)Compared with the group of non-metabolic syndrome,1-h PG is higher in the group of MS and the difference was statistically significant(P <0.05).( 7) With potatoes, fruits, vegetables intake increasing, 1-h PG levels have decreased, but only in the group of potatoes, thedifference was statistically significant(P <0.05); with increasing intake of meat, the 1-h PG levels has an increasing tendency, but not statistically significant(P >0.05).(8)In male subjects, the smoking group ’s 1-h PG level is higher than non-smokers group, the difference was statistically significant(P <0.05). In female subjects, although smoking group ￠ s 1-h PG level is higher than that in non-smokers, but the difference was not statistically significant(P> 0.05).(9)In the general population, although drinkers’ s 1-h PG levels were lower than that in non-drinkers ’ s, but the difference was not statistically significant(P> 0.05); Further analysis revealed that drinkers ’s 1-h PG level was higher than non-drinkers ’ s in male population, the difference was statistically significant(P <0.05), while in female population, drinkers’ s 1-h PG levels were lower than non-drinkers’ s, but the difference was not statistically significant(P> 0.05).(10)In the general population,using single factor Logistic regression analysis showed that1-h PG levels were correlated with gender, age, potato intake, and systolic blood pressure, diastolic blood pressure, serum creatinine, LDL-c, TC, TG, ALT, AST, γ-GT,MS, Multivariate regression analysis,showed that age, SBP, LDL-c, TG, ALT, γ-GT,MS, potato intake affects 1-h PG level and these were independent factors. Increase potato intake may reduce the risk of elevating 1-h PGlevel.While aging, SBP, LDL-c,TG, ALT, γ-GT, MS increase the risk of elevating1-h PG levels.Using multivariate regression analysis in NGT1 group and NGT2 groupresperctively showedthat :in NGT1 group, LDL-c, AST, MS wereindependent factors,and may increase the risk of elevating1-h PG levels.,while In NGT2 group, age, SBP and TG were 1-h PG levels ’s independent factors, and may increase the risk of elevating 1-h PG levels.Conclusion (1)In NGT population,With the increase of 1-h PG levels, the risk of development of MS was increased.(2)In NGT population, gender, age, food intake of potatoes, SBP, DBP, serum creatinine, LDL-c, TC, TG, ALT, AST, γ-GT, MS are theindependent factors of 1-h PG levels. Under thedifferent state of 1-h PGlevels, there may be some differences in influential factors. |
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