Observation Of The Efficacy Of Piwei Peiyuanfang In Treating CAG Of The Spleen-Stomach Deficiency Pattern

Purpose:By observing the clinical effect of Piwei Peiyuanfang in treating CAG (chronic atrophic gastritis) of the spleen-stomach deficiency pattern and the pathological changes of the patients, we intend to give play to the advantages of traditional Chinese medicine and provide clinical data for improving the clinical efficacy of the treatment of CAG and further exploring its working mechanism.Method:Take the outpatients and inpatients of the Second Affiliated Hospital of Anhui University of Chinese Medicine received from January 2014to March 2015 as the study objects, randomize the 60 cases of CAG patients of spleen-stomach deficiency pattern meeting the inclusion criteria into two groups,30 cases to each group:the treatment group is administered oral Peiwei Peiyuanfang, the control group is administered oral Weifuchun, three months is taken as a treatment course, one course altogether. Changes of the integral of clinical symptom, overall response rate, efficacy level, pathological quantization standard, pepsinogen detection results of each group are observed both before and after the treatment course.Results:(1) Comparison of integral of clinical symptom:after a treatment course, in contrast to the pre-treatment, except the difference of tongue body and coating displaying statistical significance (P< 0.05), the comparison of all other symptoms show significant statistical difference (P< 0.01); the control group displays significant comparative difference (P< 0.01) in terms of dull stomachache, distention and fullness and anorexia, shows statistical significance in terms of preferring warmth and pressure, reduced appetite (P< 0.05), all of other symptoms are improved, but the difference shows no statistical significance(P> 0.05), indicating that the integral of clinical symptom of both groups declines over the time before the treatment, but the treatment group excels the control group in improving clinical symptoms.(2) Comparison of efficacy level of TCM syndrome and overall response rate: after a treatment course, the difference between the treatment group and the control group reveals statistical significance (P<0.05), indicating better effect of the treatment group than the control group.(3) Comparison of pathological quantification standard:after a treatment course, the difference within the treatment group and between the treatment group and control group shows statistical significance (P<0.05) before and after the treatment, indicating that the treatment group is superior to the control group in improving the pathological changes of CAG patients.(4) Comparison of pepsinogen detection results:after a treatment course, the difference within the treatment group and between the treatment group and control group demonstrates statistical significance (P<0.05), indicating better performance of the treatment group than the control group in improving the pathological changes of CAG patients.