Observation Of The Therapeutic Effect Of Jin’s Epilepsy Combination Combining With Oxcarbazepine On Treating Pediatrics Partial Seizure

ObjectiveIn this research, we observe the effect of Jin’s epilepsy combination on the EEG and sleep quality of pediatric patients with partial seizure and assess the long-term safety and therapeutic effect of Jin’s epilepsy combination combining with Oxcarbazepine on treating pediatric partial seizure in order to establish a safe, effective, economical complimentary approach for the long-term treatment and management of pediatric epilepsy.Methods62 children from the pediatric unit of The Second Hospital of Third Military University who met the diagnose and inclusive criteria but not the exclusive criteria were included in this study. All Subjects were randomly divide into two groups.30 children were allocated to group 1, whereas 32 children were allocated to group 2.Subjects from group 1 received combined treatment of Jin’s epilepsy combination with Oxcarbazepine for 8 weeks. Subjects from group 2 received treatment of Oxcarbazepine for 8 weeks. EEG were record and sleep quality questionnaire were collected before the treatment,4 weeks later and 8 weeks later. Side effects were compared between both groups during the treatment and during the six months post-treatment follow up to access the long-term safety of Jin’s epilepsy combination on treating pediatric partial seizure.A six months post-treatment follow up on both groups were carried out to access the long-term therapeutic effect of Jin’s epilepsy combination on treating pediatric partial seizure.ResultsBoth groups showed statistically significant difference in reducing slow waves band power, increasing fast waves band power, improving quantitative EEG, but group 1 rendered better improvement. Group 1 showed statistical significant difference in improving abnormal EEG which is also significantly better than group 2 after 2nd treatment courses (4 weeks a treatment course) Both groups showed statistically significant difference in improving sleep quality, but group 1 rendered better improvement which manifested in improving sleep behavior and daytime drowsiness. Both groups showed statistically significant difference in extending length of sleep, but group 1 rendered better improvement, which achieve maximum effect after the 1st treatment course. Group 1 showed statistically significant difference in alleviating sleep disorder after 2nd treatment course. Group 1 achieved 96.67% effective rate which is better than the 84.38% effective rate in group 2 during the six months follow up after 2nd treatment course. Severe side effects were not observed during treatment and in the six months follow up after 2nd treatment course. Both groups showed no significant difference in mild side effects. The long-term therapeutic effect rate on group 1 is better than group 2.ConclusionJin’s epilepsy combination combined with Oxcarbazepine can improve quantitative EEG and sleep quality in pediatric patients with partial seizure. Sleep quality improvement is mostly attributed by the improvement of sleep behavior and daytime drowsiness. Jin’s epilepsy combination can treat epilepsy comorbidity with alleviation on sleep disorder. Jin’s epilepsy combination combined with Oxcarbazepine achieved 96.67% long-term effective rate with long-term safety and reliability, which is better than the 84.38% effective rate in group 2. Jin’s epilepsy combination is very suitable for the long-term treatment and management of children with epilepsy.