Toxicology Stuties Of Wushengyin

Multi-version of "Internal Medicine" teaching and "Clinical Practice Guidelines-Epilepsy volumes" accepte five drink as a treatment for epilepsy female representative party. Five drink is constituted of Health Southern Star, Pinellia, raw white tuber, Radix, black beans. And "Yu Yi · Volume Ⅳ MICRO eleven" Zhongnan Li five pills contained the same. "The wind epilepsy sputum, vaginal wiry pulse slow person, five pills Lord." Most prescription drugs toxic. And there is a "Eighteen anti" of "Pinellia" and "Radix" medicine right. Today a small number of clinical studies have reported only visible to drink five class parties.ObjectiveResearch Wushengyin of acute and chronic toxicity experiments.MethodsAcute toxicological experiments the mice were divided into 4 groups:Minus Wushengyin decoction group、Wushengyin decoction group、Wushengyin Suspension group、normal saline group. Corresponding to the amount of drug administered orally once a maximum, The mice were observed appearance, behavior, mental status, loss of appetite, urine, etc., Continuous observation of seven days. Chronic toxicological experiment the rats were divided into six groups:Minus Wushengyin decoction group、Wushengyin decoction of low-dose group, middle dose group and high dose group、Wushengyin Suspension group、 normal saline group. Day according to 1.5ml/100g drug orally once Ⅰ accordingly, Intragastric two weeks, Blood for blood routine、biochemical tests and pathological tissue. The remaining rats were then observed weekly for 2 weeks. Drawn from the above examination.ResultsAcute toxicity test:Groups of mice were not there died, The mice in good spirits, Appearance, behavior, appetite and urine normal. Chronic toxicological experiment:Poor mental state of rats in Wushengyin Suspension group, The remaining five groups rats better mental state.No significant difference in body weight of each group. Minus Wushengyin decoction and Wushengyin Suspension group set high mortality. White blood cells in Wushengyin Suspension group was higher than the saline group, White blood cells, red blood cells, hemoglobin and platelets in Minus Wushengyin decoction group were lower than the saline group.Creatinine in Minus Wushengyin decoction group set higher than the saline group. Total bilirubin in Wushengyin decoction group, aspartate aminotransferase, alanine aminotransferase greater than the saline group. Pathological examination in Wushengyin suspension group suffered most serious damage.ConelusionAcute toxicity to drink five obvious. Acute toxicity to Wushengyin obvious. Long-term administration, Minus Wushengyin decoction group、 Wushengyin decoction of high dose group and Wushengyin Suspension without boiling suspension of five may have some toxicity.