| Objective Evaluate clinical efficacy and safety of Liver-Soothing &Spleen-Strengthening treatment in treating chronic hepatitis B through observations after applying the treatment on patients with this disease.Methods All cases are from liver disease department of Taihe Hospital of Traditional Chinese Medicine including both inpatients and outpatients between December 2013 and May 2014 60 patients with chronic hepatitis B(inpatients15, outpatients 45) were divided into two groups randomly. Patients from both groups had been treated with Adefovir Dipivoxil, Diammonium Glycyrrhizinate and Thymic Peptide as basic treatment. On top that, controlled group been applied with Liver-Soothing & Spleen-Strengthening Treatment and key indicators such as clinical syndromes, liver function, HBV-DNA, etc. been observed and recorded in application SPSS13.0. Clinical efficacy have been evaluate by comparing changes in clinical syndrome, liver function and HBV-DNA for patients before and after the Treatment been applied.Conclusions(1)comparsion of the comprehensive therapeutic effect : treatment after24 weeks, the treatment group of 30 cases, complete response 3 cases(10%),partial response 17cases(56.7%), nonresponse 10 cases(33.3%), total efficiency rate 66.7%; the control group of 28 cases, complete response 2cases(7.1%), partial response 7 cases(25%),nonresponse 19 cases(67.9%),total efficiency rate 32.1%,the treatment group is better than the control group in total efficiency rate(P ﹤ 0.05).( 2) comparsion of the therapeutic effect of TCM syndrome: the treatment group of 30 cases, clinicalcure 9 cases, pindolol on action 9 cases, effective 7 cases, invalid 5 cases, the total effective rate 83.3%, the control group of 28 cases, clinical cure in 5cases, pindolol on action 2 cases, effective 12 cases, invalid 9 cases, total effective 67.9%,the treatment group to ease the patient’s symptoms and to decrease integral of clinical symptoms are obviously better than the control group(P ﹤ 0.05);(3)comparsion of liver function: after12 week,24week,the two groups in the lower ALT, AST, TBil, γ-GT, ALP both have varying degrees of improvement(P ﹤ 0.05);curing group was superior to the control group in reducing the ALT, ALP(P ﹤ 0.05).Conclusions:Liver-Soothing & Spleen-Strengthening Treatment shows certain effect on improving clinical symptoms, stabilizing liver function, elevating albumin, etc.However, it has no significant effect in reducing the quantity of the hepatitis B virus. |
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