Expression Of Wnt-1 And β-catenin In Cervical Squamous Cell Carcinomas And Their Relationship To Metastasis

Purpose: To investigate the expression of Wnt-1 and β-catenin protein in cervical squamous cell carcinomas(CSCC) and their relationship to invasion and lymph node metastasis.Methods : Expression of Wnt-1 and β-catenin protein were examined on immunohistochemistry containing 78 specimens of CSCC and 30 specimens of normal cervical tissues.Results: The positive rates of Wnt-1 and β-catenin protein in normal cervical tissues were20.0%.and10.0% respectively. The positive rates of Wnt-1 and β-catenin protein in CSCC were 56.4% and 74.4% respectively.There was a extremely difference between the two groups(P<0.001). The positive rates of Wnt-1 and β-catenin protein in 33 cases with lymph node metastasis of CSCC were 72.7% and 90.9% respectively. The positive rates of Wnt-1 and β-catenin protein in 45 cases with no lymph node metastasis of CSCC were 44.4% and 62.2% respectively, there was a extremely difference between the two groups(P<0.05)。The expression of Wnt-1 and β-catenin protein was significantly related with grades of tumors(P<0.05), Depth of invasion(P<0.05), and FIGO stages(P<0.05). And there was no significantly different between the expression of Wnt-1 and β-catenin protein and CSCC patients age(P>0.05). Spearman analysis shows that the expression of Wnt-1 protein was positive related to the expression of β-catenin protein(rs=0.490, P<0.001).Conclusion: The abnormal expression of Wnt-1 and β-catenin may be involved in the initiation, development, invasion, and metastasis of CSCC, and it is suggested that Wnt-1 and β-catenin should be considered as potential markers for invasion, metastasis, and prognosis.