The Application Of The Co-detection Of Hcy And BNP In Coronary Artery Heart Disease

Objective: To evaluate the application of the co-detection of Hcy and BNP in coronary artery heart disease.Methods: From September 2011 to September 2012, 475 cases of patients with CHD evidenced by clinical manifestation and coronary angiography(CAG)and 138 cases of people without coronary history and with normal CAG were selected, who were divided into the CHD group including Single lesion group, double lesions group, triple lesions group. At the same time the CHD group were divided into 3 groups by diagnosis: myocardial infarction group(185 patients), unstable angina group(171 patients) and stable angina group(119 patients). All people were ethnic Han, no kinship, from Tangshan area. The history of smoking, hypertension, diabetes, high cholesterol and other risk factors of coronary heart disease were asked in detail, excluded to Cerebrovascular disease, chronic renal insufficiency, chronic hepatic insufficiency, heart failure, lung disease, tumor, or drugs and etc that can lead to the rising of Hcy and BNP. The individuals were not repeated, and all patients signed the informed consent before coronary angiography and drawing blood. Plasma BNP and Hcy were measured before operation. We calculated the coronary artery lesions among the groups after coronary artery angiography and evaluated the coronary artery stenosis degree according to the Gensini score system. We compared the level of Hcy and BNP in all groups and analyzed the correlation between Hcy, BNP and the score of Gensini. The degree of coronary artery lesions. We followed up the patients in CHD group for 1 year, recording the major adverse cardiovascular events and analyzing the relationship between cardiovascular events and Hcy, BNP. Using SPSS 13.0 statistical software for statistical analysis(correlation with correlation analysis, count data comparison with χ2 test), we defined P < 0.05 as statistical significance.Results: AMI and UAP group, SAP group and the control group, the plasma BNP levels respectively(152.59±57.78),(89.34±26.67),(50.40±20.21),(41.68±8.16)pg/m L; AMI and UAP group, SAP group and the control group, plasma homocysteine levels respectively(27.3±13.67),(19.34±13.19),(13.59±3.84),(8.82±2.23)mmol/l. The levels of Hcy and BNP in Coronaryheart disease groups were higher than control group, and compared with the control group was statistically significant(P < 0.05). In the Coronaryheart disease group, the Hcy and BNP levels of acute myocardial infarction was higer than unstable angina, the unstable angina was higer than stable angina. Spearman analysis showed that there was a positive correlafion between the BNP levels and coronary lesion vessels(r1 =0.251), also between BNP and comnary lesion score(r2 =0.554). The level of BNP and Hcy in the patients with three stenosis bran ches were higher than that of two stenosis branches and the level of BNP and Hcy were higher in two stenosis branches than in single one branch(P <0.05). There were 32(6.7%) MACE during the follow-up one period, they had higher level of BNP and Hcy than the patients without MACE.Conclusions: The plasma Hcy and BNP level of the patients with CHD was higher than that of the normal people. Furthermore, the more vessels involved, the higher level of Hcy, BNP. As a good biochemical indicator screening for cardiovascular disease, it has a great sign ificance on the early diagnosis and treatment of CHD.