Influence Of Betahistine On The Expression Of Histamine H3 Receptor In The Medial Vestibular Nucleus After Unilateral Labyrinthectomy

Objective:To observe the influence of betahistine on the expression of histamine H3 receptor in the medial vestibular nucleus (MVN) following unilateral labyrinthectomy (UL). Methods:Fifty-six healthy guinea pigs were randomly divided into three group:the sham-operated group (group Ⅰ), the UL group[groupⅡ, and UL+betahistine (BET) group(group Ⅲ)], betahistine was intraperitioneally injection at 2.17 mg·kg-1·d-1 for 7 days.The expression of histamine H3 receptor was analyzed by immunohistochemistry at 1 days,3 days and 7 days after UL. Results:Our results showed that H3 receptors were presented in the MVN and the expression of histamine H3 receptor were increased significantly in the ipsilateral MVN at 1 and 3 days after UL(P< 0.05), the change turned into the normal value at 7 days(P>0.05).In the UL+BET group,the intensity of histamine H3 receptor was lower than that in the UL at 1 days and 3 days(4.25±0.71,3.50±0.92 vs 5.75±0.71,5.50±0.93, P< 0.05).but the change turned into the normal value at 3 and 7 days(P>0.05). Conclusion:The early stage of the vestibular compensation process may be associated with the change of H3 receptor expression in MVN. In the UL+BET group the histamine H3 receptor recovered quickly.Objective:To evaluate the effectiveness of betahistine combined with canalith repositioning maneuver in treating posterior semicircular canal benign paroxysmal positional vertigo (PC-BPPV).Methods:160 patients with PC-BPPV were randomly divided into treatment group (80 cases) and control group (80 cases). The treatment group was treated by canalith repositioning procedures associated with betahistine 12mg per time,3 times daily for successive 1 month.The control group was only treated by canalith repositioning procedures. Before and after treatment were applied at UCLA dizziness questionnaire to assess.Results:The scores of patients after treatment from reatment group was lower than that of patients after treatment from control group (P< 0.01).Conclusion:Compared with canalith repositioning maneuver,betahistine combined with canalith repositioning maneuver can obviously improve vertigo and ameliorate quality of life.